Mitsuhiko Ikura

University Health Network — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

94h-index36.9kcitations473works1.62yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Protein Structure and Dynamics(69), Protein Kinase Regulation and GTPase Signaling(66), Ion channel regulation and function(48), Enzyme Structure and Function(44), Ion Channels and Receptors(37)

Publications473 total

eIF2B Selectively Anchors and Activates Mutant KRAS
2025
Author response: Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
2025Open Access
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
eLife·2025Open Access
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors
iScience·2025Open Access
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
2025Open Access
Author response: Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
2025Open Access
α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin
2025Open Access
Letermovir for Cytomegalovirus Prophylaxis in Heart Transplant Recipients
American Journal of Transplantation·2025· 1 cited
CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk
2025· 3 citedOpen Access
Author response: Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
2025Open Access
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
eLife·2025· 1 citedOpen Access
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
2025Open Access
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
2025Open Access
Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle
Journal of Molecular Biology·2025· 4 cited
α-Catenin force-sensitive binding and sequestration of LZTS2 leads to cytokinesis failure
The Journal of Cell Biology·2024· 5 citedOpen Access
Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α
Proceedings of the National Academy of Sciences·2024· 6 citedOpen Access
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation
UNC Libraries·2024Open Access
Reconstitution and characterization of <scp>BRAF</scp> in complex with 14‐3‐3 and <scp>KRAS4B</scp> on nanodiscs
Protein Science·2024· 6 citedOpen Access
Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II
European Journal of Cell Biology·2024· 5 citedOpen Access
Aromatically stacking the odds in favour of increased ORAI1 activation
Cell Calcium·2023
page 1 of 24Next →

Frequent Co-authors

Ad Bax(11), Kit I. Tong(7), Peter B. Stathopulos(6), Rolf Tschudin(5), James B. Ames(5), Atsushi Miyawaki(4), Toshiyuki Tanaka(4), Masayori Inouye(4), Kevin Truong(4), Matthew J. Smith(4), Tapas K. Mal(4), Michael J. Plevin(3), Mark B. Swindells(3), Dominique Marion(2), G. Marius Clore(2), Angela M. Gronenborn(2), Ad Bax(2), Lewis E. Kay(2), Klaus P. Hoeflich(2), Michael Overduin(2)