Helen Manne

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index222citations17works0.02yr avg
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Research Topics

Melanoma and MAPK Pathways(16), Synthesis and biological activity(9), Cancer Mechanisms and Therapy(7), Computational Drug Discovery Methods(4), Protein Kinase Regulation and GTPase Signaling(3)

Publications17 total

Supplementary Figure 1 from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
Supplementary Table 1 from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
Data from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
Data from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
Supplementary Table 2 from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
Supplementary Table 2 from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
Supplementary Table 1 from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
Supplementary Figure 1 from A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of <sup>V600E</sup>BRAF
2023Open Access
CCDC 778231: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF
Cancer Research·2010· 25 citedOpen Access
Novel Hinge Binder Improves Activity and Pharmacokinetic Properties of BRAF Inhibitors
Journal of Medicinal Chemistry·2010· 37 citedOpen Access
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds
Bioorganic & Medicinal Chemistry·2010· 30 citedOpen Access
Development of Novel, Highly Potent Inhibitors of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF): Increasing Cellular Potency through Optimization of a Distal Heteroaromatic Group
Journal of Medicinal Chemistry·2010· 28 citedOpen Access
BRAF Inhibitors Based on an Imidazo[4,5]pyridin-2-one Scaffold and a Meta Substituted Middle Ring
Journal of Medicinal Chemistry·2010· 18 citedOpen Access
Corrections to Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)
Journal of Medicinal Chemistry·2009· 1 citedOpen Access
Novel Potent BRAF Inhibitors: Toward 1 nM Compounds through Optimization of the Central Phenyl Ring
Journal of Medicinal Chemistry·2009· 46 citedOpen Access
Pyridoimidazolones as Novel Potent Inhibitors of v-Raf Murine Sarcoma Viral Oncogene Homologue B1 (BRAF)
Journal of Medicinal Chemistry·2009· 37 citedOpen Access

Frequent Co-authors

Alfonso Zambon(17), Richard Kirk(17), Richard Marais(17), Delphine Ménard(16), Steven R. Whittaker(16), Caroline J. Springer(16), Natasha Preece(12), Sareena Rana(9), Maryou Lambros(9), Jorge S. Reis‐Filho(9), Douglas Hedley(9), Ion Niculescu‐Duvaz(8), Dan Niculescu‐Duvaz(8), Bart M. J. M. Suijkerbuijk(8), Arnaud Nourry(8), Lawrence Davies(8), Lesley A. Ogilvie(8), Filipa Lopes(8), Frank Friedlos(6), Douglas Hedley(6)