Patricia D. Finn

Ardelyx (United States) — United States

Medicine · Health Sciences

19h-index1.6kcitations25works0.02yr avg
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Research Topics

Hypothalamic control of reproductive hormones(9), Regulation of Appetite and Obesity(5), Neuropeptides and Animal Physiology(5), Liver Disease Diagnosis and Treatment(3), Growth Hormone and Insulin-like Growth Factors(3)

Publications25 total

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice
American Journal of Physiology-Gastrointestinal and Liver Physiology·2019· 77 citedOpen Access
Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)
Journal of Medicinal Chemistry·2018· 33 citedOpen Access
Su1552 - RDX023-2, a Minimally Systemic, Non-Bile Acid FXR Agonist, Reduces Steatosis, Inflammation and Fibrosis in Three Mouse Models of NASH
Gastroenterology·2018
Minimally-Systemic TGR5 Agonist RDX009-01 Improves Hepatic Steatosis and Insulin Sensitivity in Western Diet-Fed Mice
Gastroenterology·2017
Discovery and Characterization of an Inhibitor of Glucosylceramide Synthase
Journal of Medicinal Chemistry·2012· 20 citedOpen Access
Discovery of a new class of glucosylceramide synthase inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 14 citedOpen Access
A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis
ACS Medicinal Chemistry Letters·2010· 91 cited
Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist #
Hepatology·2008· 204 cited
Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
Proceedings of the National Academy of Sciences·2007· 262 citedOpen Access
An Orally Active Selective Androgen Receptor Modulator Is Efficacious on Bone, Muscle, and Sex Function with Reduced Impact on Prostate
Endocrinology·2006· 136 cited
Projection from the ventral bed nucleus of the stria terminalis to the retrorubral field in rats and the effects of cells in these areas on mating in male rats versus gerbils
Hormones and Behavior·2004· 27 cited
Serotonergic Neurons Are Targets for Leptin in the Monkey<sup>1</sup>
The Journal of Clinical Endocrinology & Metabolism·2001· 71 citedOpen Access
Galanin’s Functional Significance in the Regulation of the Neuroendocrine Reproductive Axis of the Monkey
Neuroendocrinology·2000· 34 cited
Contributors
Elsevier eBooks·2000
Regulation of the Hypothalamic–Pituitary–Gonadal Axis: Role of Gonadal Steroids and Implications for the Menopause
Elsevier eBooks·2000· 5 cited
The Stimulatory Effect of Leptin on the Neuroendocrine Reproductive Axis of the Monkey<sup>1</sup>
Endocrinology·1998· 292 citedOpen Access
The regulation of galanin gene expression in gonadotropin-releasing hormone neurons
Molecular and Cellular Endocrinology·1998· 23 cited
Temporal Patterns of Gonadotropin-Releasing Hormone (GnRH), c-<i>fos</i>, and Galanin Gene Expression in GnRH Neurons Relative to the Luteinizing Hormone Surge in the Rat
Journal of Neuroscience·1998· 48 citedOpen Access
Sexual differentiation of galanin gene expression in gonadotropin- releasing hormone neurons
Endocrinology·1996· 9 cited
Sexual differentiation of galanin gene expression in gonadotropin-releasing hormone neurons.
Endocrinology·1996· 20 citedOpen Access
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Frequent Co-authors

Donald K. Clifton(6), Robert A. Steiner(5), Pauline Yahr(5), David Rodríguez(4), Samantha Koo-McCoy(4), Kenji Kozuka(4), Jeremy S. Caldwell(4), Matthew J. Cunningham(3), Mark D. Erion(3), Edward E. Cable(3), Paul D. van Poelje(3), David L. Linemeyer(3), Jon Rosen(3), A. Negro‐Vilar(3), Jill Kohler(3), Zhengfeng Jiang(3), Noah Bell(3), Jeffrey Jacobs(3), R.K. Jain(3), Matthew Siegel(3)