H. Gobind Khorana

Neuroscience · Life Sciences

62h-index13.6kcitations195works0.02yr avg
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Research Topics

Photoreceptor and optogenetics research(89), DNA and Nucleic Acid Chemistry(55), Neuroscience and Neuropharmacology Research(44), RNA and protein synthesis mechanisms(41), Receptor Mechanisms and Signaling(30)

Publications195 total

Effect of genetic modification of tyrosine-185 on the proton pump and the blue-to-purple transition in bacteriorhodopsin (bacteriorhodopsin photocycle/site-specific mutants/tyrosine deprotonation/pH dependence/protein conformation changes)
2016
Total synthesis of a gene
Resonance·2012· 9 cited
Total synthesis of a gene
DSpace@MIT (Massachusetts Institute of Technology)·2012Open Access
The Roles of Transmembrane Domain Helix-III during Rhodopsin Photoactivation
PLoS ONE·2011· 12 citedOpen Access
Location of the Retinal Chromophore in the Activated State of Rhodopsin
Journal of Biological Chemistry·2009· 91 citedOpen Access
High-Level Expression, Single-Step Immunoaffinity Purification and Characterization of Human Tetraspanin Membrane Protein CD81
PLoS ONE·2008· 31 citedOpen Access
Role of group-conserved residues in the helical core of β <sub>2</sub> -adrenergic receptor
Proceedings of the National Academy of Sciences·2007· 46 citedOpen Access
The synthesis and high‐level expression of a β<sub>2</sub>‐adrenergic receptor gene in a tetracycline‐inducible stable mammalian cell line
Protein Science·2006· 71 citedOpen Access
CXXIT. THE DODECRNUCLEOTIDE SEQUEKCE ADJOIMSG THE C-C-A END OF THE TYROSINE TRANSFER RIBOKUCLEIC ACID GENE*
2006
Total Synthesis of the Structural Gene for the Precursor of a Tyrosine Suppressor Transfer RNA from Escherichia coli
2006· 5 cited
Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge
Proceedings of the National Academy of Sciences·2004· 104 citedOpen Access
Identification of core amino acids stabilizing rhodopsin
Proceedings of the National Academy of Sciences·2004· 165 citedOpen Access
NMR Spectroscopy of Phosphorylated Wild-Type Rhodopsin:  Mobility of the Phosphorylated C-Terminus of Rhodopsin in the Dark and upon Light Activation
Biochemistry·2004· 41 cited
Retinitis Pigmentosa Rhodopsin Mutations L125R and A164V Perturb Critical Interhelical Interactions
Journal of Biological Chemistry·2003· 30 citedOpen Access
The conformations of rhodopsin, activated rhodopsin and opsin in detergent micelles and phospholipid bilayers
2003
Structure and Function in Rhodopsin:  Mapping Light-Dependent Changes in Distance between Residue 65 in Helix TM1 and Residues in the Sequence 306−319 at the Cytoplasmic End of Helix TM7 and in Helix H8
Biochemistry·2001· 96 cited
Probing the Dark State Tertiary Structure in the Cytoplasmic Domain of Rhodopsin:  Proximities between Amino Acids Deduced from Spontaneous Disulfide Bond Formation between Cys316 and Engineered Cysteines in Cytoplasmic Loop 1<sup>,</sup>
Biochemistry·2001· 25 cited
Mapping of contact sites in complex formation between light-activated rhodopsin and transducin by covalent crosslinking: Use of a chemically preactivated reagent
Proceedings of the National Academy of Sciences·2001· 99 citedOpen Access
Structure and function in rhodopsin: Mass spectrometric identification of the abnormal intradiscal disulfide bond in misfolded retinitis pigmentosa mutants
Proceedings of the National Academy of Sciences·2001· 66 citedOpen Access
The effects of replacing loop residues with structure-less linkers upon folding of bacteriorhodopsin
Biochemical Society Transactions·2000
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Frequent Co-authors

Wayne L. Hubbell(8), Christian Altenbach(6), Uttam L. RajBhandary(5), W.E. Razzell(4), Toshio Mogi(4), Maarten P. Heyn(4), D. S. Jones(4), Harald Otto(3), J.H. van de Sande(3), Kjell Kleppe(3), Kevin D. Ridge(3), Lawrence J. Stern(3), David Farrens(2), Daniel D. Oprian(2), Robert S. Molday(2), T Marti(2), M. Holz(2), R R Franke(2), Thomas P. Sakmar(2), Amos Panet(2)