David S. Klimstra

Memorial Sloan Kettering Cancer Center — United States

Medicine · Health Sciences

148h-index88.2kcitations777works21.72yr avg
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Research Topics

Pancreatic and Hepatic Oncology Research(285), Neuroendocrine Tumor Research Advances(169), Cancer Genomics and Diagnostics(127), Cholangiocarcinoma and Gallbladder Cancer Studies(120), Lung Cancer Research Studies(84)

Publications772 total

Deep proteogenomic characterization of pancreatic solid pseudopapillary neoplasm reveals unique features distinct from other pancreatic tumors
Biomarker Research·2025Open Access
Proteogenomic profiling of soft tissue leiomyosarcoma reveals distinct molecular subtypes with divergent outcomes and therapeutic vulnerabilities
2025Open Access
Mucinous cystic neoplasms of the pancreas and liver share a similar <scp>DNA</scp> methylation profile with mucinous ovarian tumors
The Journal of Pathology·2025· 1 citedOpen Access
Abstract 3824: Investigating the role of allelic imbalance in pancreatic cancer aggressiveness, survival, and therapeutic resistance
Cancer Research·2025
258 Validation of an Artificial Intelligence Algorithm for Breast Cancer Mitotic Grading
Laboratory Investigation·2025
Cholangiocarcinoma classification: current approach, relevance and challenges
Journal of Clinical Pathology·2024· 4 cited
Supplementary Data from A Genomics-Driven Artificial Intelligence&lt;b&gt;–&lt;/b&gt;Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers &lt;i&gt;CDH1&lt;/i&gt; Inactivating Mechanisms
2024Open Access
Data from A Genomics-Driven Artificial Intelligence&lt;b&gt;–&lt;/b&gt;Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers &lt;i&gt;CDH1&lt;/i&gt; Inactivating Mechanisms
2024Open Access
Proteomic basis for pancreatic acinar cell carcinoma and pancreatoblastoma as similar yet distinct entities
npj Precision Oncology·2024· 4 citedOpen Access
OmniScreen model predictions and evaluation of the MSK and TCGA datasets
arXiv (Cornell University)·2024· 3 citedOpen Access
A Genomics-Driven Artificial Intelligence <b>–</b> Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers <i>CDH1</i> Inactivating Mechanisms
Cancer Research·2024· 19 citedOpen Access
SWI/SNF Complex-Deficient Undifferentiated Carcinoma of the Pancreas: Clinicopathologic and Genomic Analysis
Modern Pathology·2024· 13 citedOpen Access
A foundation model for clinical-grade computational pathology and rare cancers detection
Nature Medicine·2024· 290 citedOpen Access
Proteogenomic characterization of pancreatic neuroendocrine tumors uncovers hypoxia and immune signatures in clinically aggressive subtypes
iScience·2024· 8 citedOpen Access
Artificial Intelligence Helps Pathologists Increase Diagnostic Accuracy and Efficiency in the Detection of Breast Cancer Lymph Node Metastases
The American Journal of Surgical Pathology·2024· 25 citedOpen Access
PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology
arXiv (Cornell University)·2024· 12 citedOpen Access
Abstract GS03-04: Novel Mechanisms of CDH1 Inactivation in Breast Invasive Lobular Carcinoma Unveiled by the Integration of Artificial Intelligence and Genomics
Cancer Research·2024
DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms
Clinical Gastroenterology and Hepatology·2024· 11 citedOpen Access
Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
Cell Reports·2024· 22 citedOpen Access
2328P Alternative molecular mechanisms underpinning breast invasive lobular carcinoma identified by genomics-driven artificial intelligence model
Annals of Oncology·2023Open Access
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Frequent Co-authors

Ralph H. Hruban(17), Volkan Adsay(11), G. Johan A. Offerhaus(7), Anirban Maitra(7), Murray F. Brennan(7), Ahmet Zehir(6), Jaclyn F. Hechtman(6), Leonard B. Saltz(6), David M. Hyman(6), Michael F. Berger(6), Olca Baştürk(6), William R. Jarnagin(6), Kevin C. Conlon(6), David B. Solit(5), Marc Ladanyi(5), Christopher L. Wolfgang(5), Luis A. Díaz(5), Jorge Albores‐Saavedra(5), Günter Klöppel(5), Daniel S. Longnecker(5)