Lakshmi D. Saraswat

Sunovion (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index698citations26works0.02yr avg
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Research Topics

Muscle Physiology and Disorders(8), Cardiomyopathy and Myosin Studies(7), Bacterial Genetics and Biotechnology(4), Enzyme Structure and Function(4), RNA and protein synthesis mechanisms(3)

Publications26 total

Structural, Kinetic, and Pharmacodynamic Mechanisms of <scp>d</scp>-Amino Acid Oxidase Inhibition by Small Molecules
Journal of Medicinal Chemistry·2013· 32 citedOpen Access
IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN
2013
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors
Bioorganic & Medicinal Chemistry·2010· 18 citedOpen Access
Evidence for an Interaction between the SH3 Domain and the N-terminal Extension of the Essential Light Chain in Class II Myosins
Journal of Molecular Biology·2007· 61 citedOpen Access
Affinity Ligand Selection from a Library of Small Molecules: Assay Development, Screening, and Application
Biotechnology Progress·2005· 6 cited
A High-Throughput Method for Enzyme Kinetic Studies
SLAS DISCOVERY·2003· 10 citedOpen Access
The Power Stroke Causes Changes in the Orientation and Mobility of the Termini of Essential Light Chain 1 of Myosin
Biochemistry·2001· 25 cited
Interaction of the N-Terminus of Chicken Skeletal Essential Light Chain 1 with F-Actin
Biochemistry·1999· 34 cited
Subunit Interactions within an Expressed Regulatory Domain of Chicken Skeletal Myosin
Journal of Biological Chemistry·1998· 9 citedOpen Access
Orientation changes of fluorescent probes at five sites on the myosin regulatory light chain during contraction of single skeletal muscle fibres
Journal of Molecular Biology·1998· 48 citedOpen Access
Cysteine mutants of light chain-2 form disulfide bonds in skeletal muscle myosin.
Journal of Biological Chemistry·1993· 18 citedOpen Access
Mapping single cysteine mutants of light chain 2 in chicken skeletal myosin.
Journal of Biological Chemistry·1992· 10 citedOpen Access
Engineered cysteine mutants of myosin light chain 2. Fluorescent analogues for structural studies.
Journal of Biological Chemistry·1991· 23 citedOpen Access
Deletion mutants as probes for localizing regions of subunit interaction in cAMP-dependent protein kinase.
Journal of Biological Chemistry·1988· 35 citedOpen Access
Deletion of cAMP-binding site B in the regulatory subunit of cAMP-dependent protein kinase alters the photoaffinity labeling of site A.
Journal of Biological Chemistry·1988· 26 citedOpen Access
cAMP‐dependent protein kinase: prototype for a family of enzymes
The FASEB Journal·1988· 99 cited
A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase.
Journal of Biological Chemistry·1988· 90 citedOpen Access
Tyrosine-371 contributes to the positive cooperativity between the two cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I
Biochemistry·1988· 39 cited
Relation Between Structure and Function in cAMP-Dependent Protein Kinases
1988· 3 cited
[31] Expression and mutagenesis of the regulatory subunit of cAMP-dependent protein kinase in Escherichia coli
Methods in enzymology on CD-ROM/Methods in enzymology·1988· 20 cited
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Frequent Co-authors

Susan S. Taylor(10), José Bubis(8), Susan Lowey(8), Seth C. Hopkins(3), Larry W. Hardy(3), Kerry L. Spear(3), Mark A. Varney(3), Janusz M. Sowadski(2), James J. Neitzel(2), Marcin Filutowicz(2), Garth E. Ringheim(2), Julian Borejdo(2), Carrie A. Bowen(2), Laurence Melnick(2), Michael A. Orsini(2), M.S. Allen(2), Patrick Koch(2), Robert J. Foglesong(2), Mustapha Soukri(2), Milan Chytil(2)