Christine A. Hrycyna

Purdue University West Lafayette — United States

Medicine · Health Sciences

40h-index7.9kcitations104works0.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(42), HIV/AIDS drug development and treatment(27), Ubiquitin and proteasome pathways(16), Click Chemistry and Applications(13), Nuclear Structure and Function(11)

Publications104 total

Upstream Proteolysis by Ste24 does not Require a C-Terminal Methyl Ester as Revealed Using 33-Residue a-Factor Precursor Peptide Substrates Synthesized via Epimerization-Free Methods
International Journal of Peptide Research and Therapeutics·2025
Upstream proteolysis by Ste24 does not require a C-terminal methyl ester as revealed using 33-residue a-factor precursor peptide substrates synthesized via epimerization-free methods
2024Open Access
Supplementary Table 1 from Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
2023Open Access
Data from Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
2023Open Access
Supplementary Figure 1 from Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
2023Open Access
Supplementary Table 1 from Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
2023Open Access
Data from Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
2023Open Access
Supplementary Figure 1 from Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
2023Open Access
Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation
ACS Chemical Biology·2022· 13 citedOpen Access
The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors
Cancer Drug Resistance·2021· 63 citedOpen Access
Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity
Journal of Medicinal Chemistry·2019· 25 citedOpen Access
Methyltransferase-like 21c methylates and stabilizes the heat shock protein Hspa8 in type I myofibers in mice
Journal of Biological Chemistry·2019· 34 citedOpen Access
Methyltransferase‐like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers
The FASEB Journal·2019· 12 citedOpen Access
Dimerization of Yeast Ste14 Isoprenylcysteine Carboxyl Methyltransferase
The FASEB Journal·2019
Elucidation of the Substrate Binding Site of the Yeast Zinc Metalloprotease, Ste24
The FASEB Journal·2019
Potential Tools for Eradicating HIV Reservoirs in the Brain: Development of Trojan Horse Prodrugs for the Inhibition of P-Glycoprotein with Anti-HIV-1 Activity
Author eBooks·2019
A Quantitative FRET Assay for the Upstream Cleavage Activity of the Integral Membrane Proteases Human ZMPSTE24 and Yeast Ste24
Methods in molecular biology·2019· 5 cited
<i>ZMPSTE24</i> missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
Disease Models & Mechanisms·2018· 34 citedOpen Access
Design and Evaluation of a One-Semester General Chemistry Course for Undergraduate Life Science Majors
Journal of Chemical Education·2018· 19 cited
a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity
Bioconjugate Chemistry·2017· 14 citedOpen Access
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Frequent Co-authors

Michael M. Gottesman(10), Suresh V. Ambudkar(8), Murali Ramachandra(7), Ira Pastan(7), Jean Chmielewski(7), Susan Michaelis(6), Karin F.K. Ejendal(5), Steven Clarke(5), Ursula A. Germann(4), Marcos M. Pires(4), Saibal Dey(3), Catherine Coffinier(3), Sarah E. Hudon(3), Stephen G. Young(3), Loren G. Fong(3), I Pastan(3), Dana Emmert(3), Hilda A. Namanja(3), Susan Michaelis(2), Emily Farber(2)