Thomas Grampp

University of Zurich — Switzerland

Neuroscience · Life Sciences

11h-index664citations20works0.52yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(12), Receptor Mechanisms and Signaling(5), Cellular transport and secretion(4), Neuroinflammation and Neurodegeneration Mechanisms(4), Calcium signaling and nucleotide metabolism(3)

Publications20 total

A PK/PD study on antihyperalgesia by an α2/3‐GABA <sub>A</sub> receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABA <sub>A</sub> receptors
British Journal of Pharmacology·2026Open Access
A PK/PD study on antihyperalgesia by an α2/3-GABA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1-GABA receptors
Universität Zürich, ZORA·2026Open Access
Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia
Frontiers in Pharmacology·2025Open Access
The E3 ubiquitin ligase MARCH1 mediates downregulation of plasma membrane GABAB receptors under ischemic conditions by inhibiting fast receptor recycling
Scientific Reports·2025· 2 citedOpen Access
ERK1/2-Dependent Phosphorylation of GABAB1(S867/T872), Controlled by CaMKIIβ, Is Required for GABAB Receptor Degradation under Physiological and Pathological Conditions
International Journal of Molecular Sciences·2023· 6 citedOpen Access
ERK1/2-dependent phosphorylation of GABAB1(S867/T872), controlled by CaMKIIbeta, is required for GABAB receptor degradation under physiological and pathological conditions
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system
2022Open Access
Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system
Life Science Alliance·2021· 17 citedOpen Access
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination
Molecular Neurobiology·2018· 25 citedOpen Access
Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination
Springer US·2018
Sustained Glutamate Receptor Activation Down-regulates GABAB Receptors by Shifting the Balance from Recycling to Lysosomal Degradation
Journal of Biological Chemistry·2010· 57 citedOpen Access
Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1
Neuroscience·2009· 24 citedOpen Access
Constitutive, agonist-accelerated, recycling and lysosomal degradation of GABAB receptors in cortical neurons
Molecular and Cellular Neuroscience·2008· 50 citedOpen Access
γ-Aminobutyric Acid Type B Receptors Are Constitutively Internalized via the Clathrin-dependent Pathway and Targeted to Lysosomes for Degradation
Journal of Biological Chemistry·2007· 54 citedOpen Access
Disruption of Glycine Transporter 1 Restricted to Forebrain Neurons Is Associated with a Procognitive and Antipsychotic Phenotypic Profile
Journal of Neuroscience·2006· 134 citedOpen Access
Subtype-selective Interaction with the Transcription Factor CCAAT/Enhancer-binding Protein (C/EBP) Homologous Protein (CHOP) Regulates Cell Surface Expression of GABAB Receptors
Journal of Biological Chemistry·2005· 38 citedOpen Access
Differential Activation of Mitogen-activated Protein Kinases in Ischemic and Anesthetic Preconditioning
Anesthesiology·2003· 75 citedOpen Access
Translocation of Protein Kinase C Isoforms to Subcellular Targets in Ischemic and Anesthetic Preconditioning
Anesthesiology·2003· 127 citedOpen Access
Development of a Gas Chromatography-Mass Spectrometry Method for Determination of Ketamine in Plasma and Its Application to Human Samples
Therapeutic Drug Monitoring·1995· 55 cited

Frequent Co-authors

Dietmar Benke(16), Louis Scheurer(3), Rebecca R Das Gupta(3), Annika Saebisch(3), Benjamin K. Yee(2), Philipp Singer(2), Joram Feldon(2), Hanns Möhler(2), Detlev Boison(2), Rafaela da Silva(2), Thomas Pasch(2), Marcus Schaub(2), Michael Zaugg(2), Kathrin Sauter(2), Khaled Zemoura(2), Karthik Balakrishnan(2), Hanns Ulrich Zeilhofer(2), Musadiq A. Bhat(2), Musadiq A. Bhat(2), Mohammad Hleihil(2)