Richard Lonsdale

Age UK — United Kingdom

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

29h-index3.1kcitations52works2.52yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(20), Metal-Catalyzed Oxygenation Mechanisms(19), Enzyme Catalysis and Immobilization(14), Computational Drug Discovery Methods(8), Microbial Metabolic Engineering and Bioproduction(8)

Publications52 total

Discovery of an orally available potent ER aminopeptidase 1 (ERAP1) inhibitor that enhances anti-tumor responses and limits inflammatory autoimmunity in vivo
2025Open Access
Abstract 4854: Alleviation of low pH induced immunosuppression through antagonism of the pH sensor GPR65 in highly glycolytic NSCLC tumors
Cancer Research·2025· 1 cited
Active Learning FEP: Impact on Performance of AL Protocol and Chemical Diversity
Journal of Chemical Theory and Computation·2025· 5 cited
Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design
ACS Medicinal Chemistry Letters·2024· 4 citedOpen Access
Abstract 4638: Predictive computational approaches to guide the covalent targeting of cysteine residues in drug discovery
Cancer Research·2018
P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping
ACS Catalysis·2018· 162 citedOpen Access
Methodology Development in Directed Evolution: Exploring Options when Applying Triple‐Code Saturation Mutagenesis
ChemBioChem·2018· 25 cited
Structure-based design of targeted covalent inhibitors
Chemical Society Reviews·2018· 328 cited
Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations
Journal of the American Chemical Society·2017· 58 citedOpen Access
Expanding the Armory: Predicting and Tuning Covalent Warhead Reactivity
Journal of Chemical Information and Modeling·2017· 173 cited
Correction: Simultaneous engineering of an enzyme’s entrance tunnel and active site: the case of monoamine oxidase MAO-N
Chemical Science·2017· 3 citedOpen Access
Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N
Chemical Science·2017· 104 citedOpen Access
Exploring productive sequence space in directed evolution using binary patterning versus conventional mutagenesis strategies
Bioresources and Bioprocessing·2016· 21 citedOpen Access
Whole‐Cell‐Catalyzed Multiple Regio‐ and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution
Angewandte Chemie·2016· 35 cited
Whole‐Cell‐Catalyzed Multiple Regio‐ and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution
Angewandte Chemie International Edition·2016· 86 cited
Synthesis, structure and stability of a chiral imine-based Schiff-based ligand derived from L-glutamic acid and its [Cu4] complex
Journal of Molecular Structure·2016· 15 cited
Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single‐ versus Double‐Code Saturation Mutagenesis
ChemBioChem·2016· 42 cited
Quantum Mechanics/Molecular Mechanics Modeling of Drug Metabolism: Mexiletine N-Hydroxylation by Cytochrome P450 1A2
Chemical Research in Toxicology·2016· 31 citedOpen Access
Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase
ACS Catalysis·2016· 138 cited
Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase
ACS Catalysis·2016· 135 cited
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Frequent Co-authors

Adrian J. Mulholland(20), Manfred T. Reetz(15), Jeremy N. Harvey(11), Zhoutong Sun(10), Adriana Ilie(7), Jiahai Zhou(5), Manfred T. Reetz(5), Aitao Li(4), Jian‐He Xu(4), Rubén Agudo(4), Carlos G. Acevedo‐Rocha(3), Nathalie Nett(3), Sabrina Hoebenreich(3), Guangyue Li(3), Xu‐Dong Kong(3), Kara E. Ranaghan(3), Peiyuan Yao(3), Manfred T. Reetz(3), Gheorghe‐Doru Roiban(3), Richard A. Ward(2)