Ganesh Routholla

Indian Institute of Chemical Technology — India

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index365citations17works5.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Histone Deacetylase Inhibitors Research(10), Peptidase Inhibition and Analysis(5), Protein Degradation and Inhibitors(5), Click Chemistry and Applications(4), Synthesis and biological activity(2)

Publications17 total

Ready Access to Benzodiazocines from Tryptamines: A Druggable Scaffold toward Antiviral Agents
ACS Medicinal Chemistry Letters·2025Open Access
Design and synthesis of pyridine-based benzamides as potent HDAC3 inhibitors as an armament against breast cancer with in vivo validation
European Journal of Medicinal Chemistry·2025· 4 cited
Pharmacological blockade of HDAC6 attenuates cancer progression by inhibiting IL-1β and modulating immunosuppressive response in OSCC
International Immunopharmacology·2024· 11 citedOpen Access
Selective HDAC3 Inhibitors with Potent In Vivo Antitumor Efficacy against Triple-Negative Breast Cancer
Journal of Medicinal Chemistry·2023· 48 citedOpen Access
Synthesis and appraisal of dalbergin-loaded PLGA nanoparticles modified with galactose against hepatocellular carcinoma: In-vitro, pharmacokinetic, and in-silico studies
Frontiers in Pharmacology·2022· 10 citedOpen Access
HDAC6 inhibition attenuates renal injury by reducing IL-1β secretion and RIP kinase mediated necroptosis in acute oxalate nephropathy
International Immunopharmacology·2022· 14 cited
Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer
European Journal of Medicinal Chemistry·2022· 38 citedOpen Access
Design, synthesis and binding mode of interaction of novel small molecule o-hydroxy benzamides as HDAC3-selective inhibitors with promising antitumor effects in 4T1-Luc breast cancer xenograft model
Bioorganic Chemistry·2021· 28 cited
Synthesis, biological evaluation, and molecular docking analysis of novel linker-less benzamide based potent and selective HDAC3 inhibitors
Bioorganic Chemistry·2021· 32 cited
PT3: A Novel Benzamide Class Histone Deacetylase 3 Inhibitor Improves Learning and Memory in Novel Object Recognition Mouse Model
ACS Chemical Neuroscience·2021· 26 cited
Quantitative activity–activity relationship (QAAR) driven design to develop hydroxamate derivatives of pentanoic acids as selective HDAC8 inhibitors: synthesis, biological evaluation and binding mode of interaction studies
New Journal of Chemistry·2021· 16 cited
HDAC6 inhibitor accelerates wound healing by inhibiting tubulin mediated IL-1β secretion in diabetic mice
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2020· 45 cited
Synthesis of α-ketoamides using potassium superoxide (KO2) as an oxidizing agent
Tetrahedron·2020· 4 cited
Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 inhibitors with promising anticancer activity
European Journal of Pharmaceutical Sciences·2019· 42 cited
2-Phenylindole derivatives as anticancer agents: synthesis and screening against murine melanoma, human lung and breast cancer cell lines
Synthetic Communications·2019· 16 cited
First Report on 3‐(3‐oxoaryl) Indole Derivatives as Anticancer Agents: Microwave Assisted Synthesis, <i>In Vitro</i> Screening and Molecular Docking Studies
ChemistrySelect·2019· 23 cited
Determination of the Absolute Configuration of Gliomasolide D through Total Syntheses of the C-17 Epimers
Journal of Natural Products·2017· 8 cited

Frequent Co-authors

Balaram Ghosh(14), Nilanjan Adhikari(7), Tarun Patel(7), Sravani Pulya(6), Swati Biswas(6), Tarun Jha(6), Onkar P. Kulkarni(4), Sk. Abdul Amin(4), Yamini Bobde(4), Milan Paul(3), Suvankar Banerjee(3), Pravesh Sharma(3), Ashutosh Mahale(3), D. Srinivasa Reddy(3), Ambati Himaja(2), Kalyani Karnam(2), Kavitha Sedmaki(2), Prakruti Trivedi(2), Ruchi Gaikwad(2), Kalpataru Das(2)