Gabriel Berstein

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.7kcitations42works4.32yr avg
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Research Topics

Receptor Mechanisms and Signaling(16), Psoriasis: Treatment and Pathogenesis(11), Neuroscience and Neuropharmacology Research(7), Protein Kinase Regulation and GTPase Signaling(7), Dermatology and Skin Diseases(7)

Publications42 total

Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity
Journal of Medicinal Chemistry·2025· 1 cited
Structural basis for CCR6 modulation by allosteric antagonists
Nature Communications·2024· 16 citedOpen Access
Structural basis for CCR6 modulation by allosteric antagonists
2024Open Access
Correction: Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
Pharmaceutical Research·2024Open Access
Comparative Study of Dermal Pharmacokinetics Between Topical Drugs Using Open Flow Microperfusion in a Pig Model
Pharmaceutical Research·2023· 6 citedOpen Access
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
Journal of Pharmacology and Experimental Therapeutics·2023· 20 citedOpen Access
Efficacy and safety of topical brepocitinib cream for mild-to-moderate chronic plaque psoriasis: a phase IIb randomized double-blind vehicle-controlled parallel-group study
British Journal of Dermatology·2023· 29 cited
RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells
Lara D. Veeken·2023· 24 citedOpen Access
Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists
ACS Medicinal Chemistry Letters·2023· 4 citedOpen Access
A phase I, randomized, double‐blind study to assess the safety, tolerability and efficacy of the topical RORC2 inverse agonist PF‐06763809 in participants with mild‐to‐moderate plaque psoriasis
Clinical and Experimental Dermatology·2020· 17 citedOpen Access
Early Quantification of Systemic Inflammatory Proteins Predicts Long-Term Treatment Response to Tofacitinib and Etanercept
Journal of Investigative Dermatology·2019· 41 cited
X-Ray Crystallography of Membrane Proteins: Concepts and Applications of Lipidic Mesophases to Three-Dimensional Membrane Protein Crystallization
2019
Reconstitution of Receptor-Promoted Signal Transduction Using Purified Receptor, G Protein, and Effector
2019
722 Type 2 helper T-cell (Th2) effects of crisaborole versus 3 topical corticosteroids (TCSs) with a range of potencies: An ex vivo human skin model study
Journal of Investigative Dermatology·2019
Discovery of 3-Cyano- <i>N</i> -(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 <i>H</i> -pyrrolo[2,3- <i>b</i> ]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist
Journal of Medicinal Chemistry·2018· 32 citedOpen Access
Association between serum interleukin-17A and clinical response to tofacitinib and etanercept in moderate to severe psoriasis
Clinical and Experimental Dermatology·2018· 25 cited
The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis
Lara D. Veeken·2018· 91 citedOpen Access
Reduction of Inflammatory and Cardiovascular Proteins in the Blood of Patients with Psoriasis: Differential Responses between Tofacitinib and Etanercept after 4 Weeks of Treatment
Journal of Investigative Dermatology·2017· 44 citedOpen Access
Ultra-Sensitive Measurement of IL-17A and IL-17F in Psoriasis Patient Serum and Skin
The AAPS Journal·2017· 51 cited
276 Reduction of cardiovascular disease-associated proteins in blood of psoriasis patients after 1-month treatment with tofacitinib or etanercept
Journal of Investigative Dermatology·2016· 1 cited
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Frequent Co-authors

Kimberly Crouse(7), Elliott M. Ross(6), James G. Krueger(6), Arata Ichiyama(6), Hernán Valdez(6), Lori Fitz(6), Mark E. Schnute(6), Jennifer Alley(6), Kazuko Haga(5), Tatsuya Haga(5), Robert Wołk(5), Andrew C. Flick(5), Philippe Nuhant(5), Atli Thorarensen(5), John I. Trujillo(5), Ray Unwalla(5), Stefanus J. Steyn(5), Gloria Biddlecome(4), Lewis E. Tomalin(4), Joel Corrêa da Rosa(4)