Gerhard Fritz

Düsseldorf University Hospital — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index8.1kcitations168works2.72yr avg
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Research Topics

DNA Repair Mechanisms(47), Cell death mechanisms and regulation(26), Protein Kinase Regulation and GTPase Signaling(19), Carcinogens and Genotoxicity Assessment(17), Cancer-related Molecular Pathways(13)

Publications168 total

Overcoming acquired doxorubicin resistance of ovarian carcinoma cells by verapamil‑mediated promotion of DNA damage‑driven cytotoxicity
International Journal of Oncology·2026Open Access
155 Pulmonary ionocyte specific CFTR reactivation restores chloride absorption and secretion in cystic fibrosis
Journal of Cystic Fibrosis·2025
149 Unlocking airway stem cell potential by manipulating Ncf1/Igfbp2 signaling
Journal of Cystic Fibrosis·2025
Mouse precision-cut liver and kidney slices: an optimized <i>ex vivo</i> model for acute toxicity testing
2025Open Access
Mx1-Cre-mediated Rac1 knockout confers multiple protective effects against anthracycline-induced acute normal tissue injury
2025Open Access
Epigenetic targeting of DNA damage response (DDR)-related mechanisms to overcome acquired cisplatin resistance of tumor cells
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2025· 1 cited
Differential responses of murine embryonic stem cells (mESC) and their endothelial progeny to doxorubicin and pharmacological inhibitors of DNA repair and DNA damage response
2025· 1 citedOpen Access
Overcoming acquired doxorubicin resistance of ovarian carcinoma cells by verapamil-mediated promotion of DNA damage-driven cell death
2025Open Access
Preconditioning of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming in iPSC-derived cardiomyocytes linked to mitochondrial dysfunction and impaired cardiac regeneration
2025· 1 citedOpen Access
Evaluation of Genotoxic Effects of N-Methyl-N-Nitroso-Urea and Etoposide on the Differentiation Potential of MSCs from Umbilical Cord Blood and Bone Marrow
Cells·2024Open Access
Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse
International Journal of Cancer·2024· 7 citedOpen Access
Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs)
Cell Death Discovery·2024· 13 citedOpen Access
Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42
Pharmacological Research·2024· 7 citedOpen Access
Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
Cell Death Discovery·2024· 10 citedOpen Access
Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin- dependent kinases (CDKs)
2024Open Access
Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2
2023Open Access
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2023· 7 cited
Nuclear RAC1 is a modulator of the doxorubicin-induced DNA damage response
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2022· 6 cited
Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death
Molecules·2022· 7 citedOpen Access
Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective
NeuroToxicology·2022· 6 cited
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Frequent Co-authors

Bernd Kaina(26), Johannes Huelsenbeck(7), Christian Henninger(7), Wynand P. Roos(5), Ingo Just(4), Arno Schad(4), Imke Tiede(3), Daniela Poppe(3), Dennis Strand(3), Stefan Wirtz(3), Christoph Becker(3), Brigitte Bartsch(3), Peter R. Galle(3), Markus F. Neurath(3), Klaus Aktories(3), Sabine Grösch(3), Tobias Nübel(3), Karl J. Lackner(3), Stefanie C. Huelsenbeck(3), Susanne Strand(2)