April Smith‐Torhan

Carolina Veterinary Specialists — United States

Neuroscience · Life Sciences

13h-index622citations14works0.02yr avg
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Research Topics

Neuropeptides and Animal Physiology(9), Receptor Mechanisms and Signaling(9), Respiratory and Cough-Related Research(4), Protein Kinase Regulation and GTPase Signaling(2), Blood Coagulation and Thrombosis Mechanisms(2)

Publications14 total

Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models
European Journal of Pharmacology·2009· 27 citedOpen Access
Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety
Bioorganic & Medicinal Chemistry Letters·2009· 14 citedOpen Access
Effect of a Novel NOP Receptor Agonist (SCH 225288) on Guinea Pig Irritant-Evoked, Feline Mechanically Induced and Canine Infectious Tracheobronchitis Cough
Pharmacology·2009· 13 cited
The Anxiolytic-Like Effects of the Novel, Orally Active Nociceptin Opioid Receptor Agonist 8-[bis(2-Methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510)
Journal of Pharmacology and Experimental Therapeutics·2008· 83 cited
Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist
Journal of Medicinal Chemistry·2006· 39 citedOpen Access
Modification of the clozapine structure by parallel synthesis
Bioorganic & Medicinal Chemistry Letters·2006· 41 citedOpen Access
Hydrazides of clozapine: A new class of D1 dopamine receptor subtype selective antagonists
Bioorganic & Medicinal Chemistry Letters·2006· 21 citedOpen Access
Antitussive Profile of the NOP Agonist Ro-64-6198 in the Guinea Pig
Pharmacology·2004· 30 cited
Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats
British Journal of Pharmacology·2003· 58 citedOpen Access
Nociceptin inhibits cough in the guinea‐pig by activation of ORL<sub>1</sub> receptors
British Journal of Pharmacology·2001· 99 citedOpen Access
SCH-202676: An Allosteric Modulator of Both Agonist and Antagonist Binding to G Protein-Coupled Receptors
Molecular Pharmacology·2001· 2 cited
SCH-202676: An Allosteric Modulator of Both Agonist and Antagonist Binding to G Protein-Coupled Receptors
Molecular Pharmacology·2001· 80 cited
Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung
European Journal of Pharmacology·2000· 56 cited
Binding of a Thrombin Receptor Tethered Ligand Analogue to Human Platelet Thrombin Receptor
Molecular Pharmacology·1997· 59 citedOpen Access

Frequent Co-authors

Ahmad Fawzi(11), Deen Tulshian(9), Hongtao Zhang(7), John A. Hey(6), Ginny D. Ho(6), Robbie L. McLeod(5), Leonard E. Parra(4), Xiomara Fernandez(4), Christine H. Erickson(3), Geoffrey B. Varty(3), Michael P. Graziano(3), Galen Carey(2), Robert W. Egan(2), Sherry Lu(2), Julius J. Matasi(2), Douglas Macdonald(2), Lawrence L. Benbow(2), Blair Weig(2), Maurine E. Linder(2), Ho-Sam Ahn(2)