Shiow‐Ju Lee

National Health Research Institutes — Taiwan

Agricultural and Biological Sciences · Life Sciences

31h-index8.8kcitations79works3.02yr avg
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Research Topics

Phytochemistry and biological activities of Ficus species(18), Traditional and Medicinal Uses of Annonaceae(13), Phytochemistry and Biological Activities(7), Peptidase Inhibition and Analysis(7), Neuropeptides and Animal Physiology(6)

Publications77 total

Synthesis and evaluation of a novel class of spiro[chromene-2,2′-indoline] derivatives as potent inhibitors of peptidylarginine deiminase IV to treat rheumatoid arthritis
European Journal of Medicinal Chemistry·2025
Corrigendum to “Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin” [Biochem. Pharmacol. 215 (2023) 115688]
Biochemical Pharmacology·2025Open Access
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice
Biochemical and Biophysical Research Communications·2024· 9 cited
Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin
Biochemical Pharmacology·2023· 14 cited
Correction: Lee et al. The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b. Pharmaceutics 2022, 14, 1511
Pharmaceutics·2023Open Access
The Synergistic Inhibition of Coronavirus Replication and Induced Cytokine Production by Ciclesonide and the Tylophorine-Based Compound Dbq33b
Pharmaceutics·2022· 2 citedOpen Access
Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch
Pharmaceuticals·2022· 4 citedOpen Access
Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2
Frontiers in Pharmacology·2021· 24 citedOpen Access
Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives
Frontiers in Pharmacology·2020· 22 citedOpen Access
Erratum to “Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis” [Biochem. Pharmacol. 180 (2020) 114122]
Biochemical Pharmacology·2020Open Access
Discovery of M Protease Inhibitors Encoded by SARS-CoV-2
Antimicrobial Agents and Chemotherapy·2020· 110 citedOpen Access
Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysis
Biochemical Pharmacology·2020· 20 citedOpen Access
Repurposing old drugs as antiviral agents for coronaviruses
Biomedical Journal·2020· 68 citedOpen Access
Artificial intelligence approach fighting COVID-19 with repurposing drugs
Biomedical Journal·2020· 227 citedOpen Access
Polyketide Synthase Gene Expression in Relation to Chloromonilicin and Melanin Production in <i>Monilinia fructicola</i>
Phytopathology·2020· 10 citedOpen Access
The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation
Biochemical Pharmacology·2019· 5 cited
Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1α
Pharmacological Research·2019· 39 cited
Correction: Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget
Oncotarget·2019· 2 citedOpen Access
The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling
Toxicology and Applied Pharmacology·2018· 36 citedOpen Access
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity
Scientific Reports·2017· 67 citedOpen Access
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Frequent Co-authors

Cheng‐Wei Yang(28), Yue‐Zhi Lee(18), Hsing‐Yu Hsu(12), Hsun‐Shuo Chang(12), Yu‐Sheng Chao(10), Ih‐Sheng Chen(8), Chiung-Tong Chen(6), Weir‐Torn Jiaang(6), Szu-Huei Wu(5), Huey‐Kang Sytwu(5), Hsing-Yu Hsu(5), Hsin-Yu Chang(5), Ming‐Jen Cheng(5), Ruey‐Bing Yang(5), Tzu-Ting Peng(4), Pei‐Lin Wu(4), Ssu‐Hui Wu(4), Chia‐Hui Chien(4), Yi-Yu Ke(3), Teng-Kuang Yeh(3)