Alexandru‐Florian Deftu

University of Lausanne — Switzerland

Medicine · Health Sciences

12h-index304citations31works4.02yr avg
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Research Topics

Pain Mechanisms and Treatments(11), Neuroinflammation and Neurodegeneration Mechanisms(8), Neuroscience and Neuropharmacology Research(6), Nerve injury and regeneration(5), Ion Channels and Receptors(4)

Publications31 total

A combined activity of peripheral nociceptive and nonnociceptive neurons is necessary to trigger spinal microglial reactivity and sustained pain
Pain·2025Open Access
Dorsal root ganglia <scp>CSF1</scp><sup>+</sup> neuronal subtypes have different impact on macrophages and microglia after spared nerve injury
Journal of the Peripheral Nervous System·2024· 2 citedOpen Access
Electrophysiological properties of dorsal root ganglion neurons cultured on 3D silicon micro-pillar substrates
Journal of Neuroscience Methods·2024· 10 cited
Potassium channel modulation in macrophages sensitizes dorsal root ganglion neurons after nerve injury
Glia·2023· 8 citedOpen Access
Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury
International Journal of Molecular Sciences·2023· 25 citedOpen Access
Data from: Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Data from: Characterisation of GFAP-Expressing Glial Cells in the Dorsal Root Ganglion after Spared Nerve Injury
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Data from: Kir2.1 modulation in macrophages sensitises dorsal root ganglion neurons through TNF secretion after nerve injury
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Data from: Kir2.1 modulation in macrophages sensitises dorsal root ganglion neurons through TNF secretion after nerve injury
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
K <sub>ir</sub> 2.1 modulation in macrophages sensitises dorsal root ganglion neurons through TNF secretion after nerve injury
2023Open Access
Microglial morphology in the somatosensory cortex across lifespan. A quantitative study
Developmental Dynamics·2023· 13 citedOpen Access
The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na<sub>V</sub>1.7 via the Ubiquitin-Ligase NEDD4-2
eNeuro·2022· 15 citedOpen Access
Roles of Microglial Ion Channel in Neurodegenerative Diseases
Journal of Clinical Medicine·2021· 24 citedOpen Access
Potassium Channels Kv1.3 and Kir2.1 But Not Kv1.5 Contribute to BV2 Cell Line and Primary Microglial Migration
International Journal of Molecular Sciences·2021· 18 citedOpen Access
The inhibition of Kir2.1 potassium channels depolarizes spinal microglial cells, reduces their proliferation, and attenuates neuropathic pain
Glia·2020· 26 cited
Silencing the Cytoskeleton Protein Iba1 (Ionized Calcium Binding Adapter Protein 1) Interferes with BV2 Microglia Functioning
Cellular and Molecular Neurobiology·2020· 35 citedOpen Access
Glia and Pain in Spinal Cord
Elsevier eBooks·2020
Contributors
Elsevier eBooks·2019
Exosomes as intercellular communication messengers for cardiovascular and cerebrovascular diseases
Elsevier eBooks·2019· 11 cited
Development of a new CiPA-compliant MOA in vitro assay on stem cell-derived cardiomyocytes including automated data analysis and model parameter optimization
Journal of Pharmacological and Toxicological Methods·2019
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Frequent Co-authors

Marc R. Suter(13), Violeta Ristoiu(12), Guylène Kirschmann(9), Isabelle Décosterd(9), Elena A. Konnova(7), Paul Chu Sin Chung(7), Roxana Gheorghe(6), Alexandru Filippi(6), Beatrice Mihaela Radu(4), Marie Pertin(4), Andreea Grosu(3), Gabriela Chirițoiu(3), Bogdan Amuzescu(3), Bogdan Cătălin(3), Aurel Popa‐Wagner(3), Antonia Teona Deftu(3), Marioara Chiritoiu‐Butnaru(2), Christophe Gattlen(2), Stefan A. Mann(2), Juliane Heide(2)