Parvez Alam

Oldham Council — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index4.0kcitations82works6.92yr avg
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Research Topics

Protein Interaction Studies and Fluorescence Analysis(31), Alzheimer's disease research and treatments(24), Drug Transport and Resistance Mechanisms(20), Computational Drug Discovery Methods(13), Parkinson's Disease Mechanisms and Treatments(12)

Publications82 total

Relationships of central synucleinopathy with catecholamine deficiency in Parkinson’s disease, pure autonomic failure, and multiple system atrophy
SSRN Electronic Journal·2026Open Access
Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets
Microbiology and Molecular Biology Reviews·2025· 1 citedOpen Access
Evidence against efficient spontaneous disassembly of prions into small oligomers
Journal of Biological Chemistry·2025· 2 citedOpen Access
Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43
2025Open Access
Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer’s disease
Scientific Reports·2025· 2 citedOpen Access
“Body-first” dementia with Lewy bodies
Clinical Autonomic Research·2025· 2 cited
A same day α-synuclein RT-QuIC seed amplification assay for synucleinopathy biospecimens
npj Biosensing·2025· 15 citedOpen Access
Elevated Cerebrospinal Fluid α‐Synuclein Seeding Activity Predicts Central Lewy Body Diseases
Movement Disorders Clinical Practice·2025· 5 citedOpen Access
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Acta Neuropathologica·2024· 21 citedOpen Access
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries
Fluids and Barriers of the CNS·2024· 1 citedOpen Access
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
2024· 1 citedOpen Access
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Acta Neuropathologica·2024· 9 citedOpen Access
Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation
Journal of Biological Chemistry·2024· 2 citedOpen Access
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning
Nature Chemical Biology·2024· 35 citedOpen Access
Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions
Chemical Science·2023· 5 citedOpen Access
A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
Journal of Biological Chemistry·2022· 13 citedOpen Access
Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
PLoS Pathogens·2022· 55 citedOpen Access
Drug repurposing screens identifies compounds that inhibit α-synuclein oligomers’ membrane disruption and block antibody interactions
2022· 1 citedOpen Access
Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
2022· 4 citedOpen Access
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers
Fluids and Barriers of the CNS·2022· 37 citedOpen Access
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Frequent Co-authors

Rizwan Hasan Khan(42), Mohammad Khursheed Siddiqi(21), Sumit Kumar Chaturvedi(19), Saima Nusrat(12), Masihuz Zaman(10), Nida Zaidi(10), Gamal Badr(9), Mohammad Rehan Ajmal(9), Ali S. Abdelhameed(8), Sadia Malik(8), Mohamed H. Mahmoud(7), Mohd Rehan Ajmal(6), Mohsin Vahid Khan(6), Javed Masood Khan(5), Nabeela Majid(5), Ravi Kant Rajpoot(4), Yasser E. Shahein(4), Daniel E. Otzen(3), Atiyatul Qadeer(3), Byron Caughey(3)