Amy F.T. Arnsten

Yale University — United States

Neuroscience · Life Sciences

84h-index31.7kcitations259works4.22yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(101), Memory and Neural Mechanisms(79), Alzheimer's disease research and treatments(46), Attention Deficit Hyperactivity Disorder(42), Functional Brain Connectivity Studies(40)

Publications259 total

Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness
Molecular Psychiatry·2025Open Access
Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer’s disease
2025Open Access
A novel multimodal pharmacologic approach using guanfacine, N-acetylcysteine, and donepezil in severe TBI: a case series
Frontiers in Rehabilitation Sciences·2025Open Access
Ryanodine receptor 2–mediated calcium leak is associated with increased glyoxalase I in the aging brain
JCI Insight·2025· 1 citedOpen Access
Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance
Translational Psychiatry·2025Open Access
An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease
Alzheimer s & Dementia·2025· 13 citedOpen Access
Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology
Frontiers in Aging Neuroscience·2025· 1 citedOpen Access
Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques
Communications Biology·2025· 3 citedOpen Access
Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation
Frontiers in Aging Neuroscience·2025· 3 citedOpen Access
472. Role of Voltage-Gated Calcium Channels in Vulnerable Pyramidal Neurons in Primate Dorsolateral Prefrontal Cortex: Elucidating the Role of Cav3.1 and Cav1.2 in Higher-Order Cognition
Biological Psychiatry·2025
Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices
Frontiers in Neuroanatomy·2025· 1 citedOpen Access
39 Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration
Journal of Clinical and Translational Science·2025Open Access
From comparative connectomics to large-scale working memory modeling in macaque and marmoset
2025· 1 citedOpen Access
The neuropathologic basis for translational biomarker development in the macaque model of late-onset Alzheimer's disease
Journal of Alzheimer s Disease·2025· 3 citedOpen Access
SUSCEPTIBLE PYRAMIDAL NEURONS IN PRIMATE DORSOLATERAL PREFRONTAL CORTEX EXPRESS AN ENRICHED CALCIUM INTERACTOME: CRITICAL ROLE OF CALBINDIN AND CAV1.2 IN HIGHER-ORDER COGNITION
The International Journal of Neuropsychopharmacology·2025Open Access
The etiology and prevention of early‐stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques
Alzheimer s & Dementia·2025· 6 citedOpen Access
The circuit mechanisms of working memory: Key roles of the dorsolateral prefrontal cortex
Elsevier eBooks·2024
Inhibition of brain glutamate carboxypeptidase II (GCPII) to enhance cognitive function
Advances in pharmacology·2024· 2 citedOpen Access
Prefrontal Cortical NR2B-Containing NMDA Receptors are Essential for Spatial Working Memory Performance
2024Open Access
Kynurenic acid inflammatory signaling expands in primates and impairs prefrontal cortical cognition
2024· 3 citedOpen Access
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Frequent Co-authors

Min Wang(7), Shari G. Birnbaum(4), Susheel Vijayraghavan(3), Jane R. Taylor(3), Brian P. Ramos(3), Constantinos D. Paspalas(3), James A. Mazer(3), Yang Yang(3), Nao J. Gamo(3), Lu E. Jin(3), Christopher H. van Dyck(3), Rex G. Mathew(2), Avis R. Brennan(2), Anne G. Dudley(2), Patricia S. Goldman‐Rakic(2), Beth L. Murphy(2), P.S. Goldman-Rakic(2), Xiao‐Jing Wang(2), Daeyeol Lee(2), Adam P. Mecca(2)