Scott Lew

Columbia University — United States

Materials Science · Physical Sciences

19h-index1.4kcitations40works0.52yr avg
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Research Topics

Enzyme Structure and Function(13), Amino Acid Enzymes and Metabolism(5), Lipid Membrane Structure and Behavior(4), Protein Structure and Dynamics(3), Photosynthetic Processes and Mechanisms(3)

Publications40 total

Crystal structure of human Cep57 C‐terminal domain reveals the presence of leucine zipper and the potential microtubule binding region
Proteins Structure Function and Bioinformatics·2024· 1 cited
Author response for "Crystal structure of human Cep57 C‐terminal domain reveals the presence of leucine zipper and the potential microtubule binding region"
2024
Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160
2018
Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia
Cancer Cell·2018· 53 citedOpen Access
Abstract PR02: Mechanisms of NT5C2 activating mutations driving thiopurine resistance in relapsed lymphoblastic leukemia
Clinical Cancer Research·2017
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
Scientific Reports·2016· 96 citedOpen Access
Using a second‐order differential model to fit data without baselines in protein isothermal chemical denaturation
Protein Science·2016· 4 citedOpen Access
Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis
Proceedings of the National Academy of Sciences·2014· 121 citedOpen Access
Crystal structure of human COQ9 in complex with a phospholipid, Northeast Structural Genomics Consortium Target HR5043
2014
A novel architecture of 600 kDa bacterial citrate lyase complex
Acta Crystallographica Section A Foundations and Advances·2014Open Access
Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19
ACS Chemical Biology·2014· 29 citedOpen Access
Design of activated serine–containing catalytic triads with atomic-level accuracy
Nature Chemical Biology·2014· 86 citedOpen Access
Allosteric regulation and substrate activation in cytosolic nucleotidase<scp>II</scp>from<i><scp>L</scp>egionella pneumophila</i>
FEBS Journal·2014· 25 citedOpen Access
Crystal structure of cytosolic nucleotidase II (LPG0095) in complex with GMP from Legionella pneumophila, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET LGR1
2014
Structural and Biochemical Characterization of the Bilin Lyase CpcS from Thermosynechococcus elongatus
Biochemistry·2013· 33 cited
A Bidirectional System for the Dynamic Small Molecule Control of Intracellular Fusion Proteins
ACS Chemical Biology·2013· 51 citedOpen Access
Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy
Journal of the American Chemical Society·2013· 112 citedOpen Access
Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations
Structure·2013· 21 citedOpen Access
Crystal structure of the evolved variant of the computationally designed serine hydrolase, OSH55.4_H1, covalently bound with diisopropyl fluorophosphate (DFP), Northeast Structural Genomics Consortium (NESG) Target OR273
2013
Crystal structure of the improved variant of the evolved serine hydrolase, OSH55.4_H1.2, bond with sulfate ion in the active site, Northeast Structural Genomics Consortium (NESG) Target OR301
2013
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Frequent Co-authors

J. Seetharaman(32), F. Forouhar(23), G.T. Montelione(23), Liang Tong(17), J.K. Everett(17), J.F. Hunt(16), Rong Xiao(14), T.B. Acton(10), Thomas Acton(9), Erwin London(5), Min Su(5), S. Sahdev(5), C. Ciccosanti(5), A.P. Kuzin(4), David Baker(4), Michael A. Kennedy(4), Jianhua Ren(3), S. Rajagopalan(3), Theresa A. Ramelot(3), M. Abashidze(3)