Alexander Constantinides

University Medical Center Utrecht — Netherlands

Medicine · Health Sciences

10h-index389citations17works4.32yr avg
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Research Topics

Intraperitoneal and Appendiceal Malignancies(9), Appendicitis Diagnosis and Management(5), Hepatocellular Carcinoma Treatment and Prognosis(4), Diabetes, Cardiovascular Risks, and Lipoproteins(3), Lipoproteins and Cardiovascular Health(3)

Publications17 total

Treatment of colorectal peritoneal metastases with oxaliplatin induces biomarkers predicting response to immune checkpoint blockade
Translational Oncology·2025· 1 citedOpen Access
First-line palliative systemic therapy alternated with oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: A single-arm phase II trial (CRC-PIPAC-II)
European Journal of Surgical Oncology·2024· 5 cited
Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases
Cell Reports Medicine·2024· 7 citedOpen Access
Palliative systemic therapy and oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy in patients with unresectable colorectal peritoneal metastases in a phase II trial (CRC-PIPAC-II)
European Journal of Surgical Oncology·2023
Consensus molecular subtype 4 (CMS4)-targeted therapy in primary colon cancer: A proof-of-concept study
Frontiers in Oncology·2022· 29 citedOpen Access
Peritoneal metastases from colorectal cancer belong to Consensus Molecular Subtype 4 and are sensitised to oxaliplatin by inhibiting reducing capacity
British Journal of Cancer·2022· 61 citedOpen Access
First-line palliative systemic therapy alternated with electrostatic pressurised intraperitoneal aerosol chemotherapy (oxaliplatin) for isolated unresectable colorectal peritoneal metastases: protocol of a multicentre, single-arm, phase II study (CRC-PIPAC-II)
BMJ Open·2021· 13 citedOpen Access
Detection of tumor‐derived cell‐free <scp>DNA</scp> from colorectal cancer peritoneal metastases in plasma and peritoneal fluid
The Journal of Pathology Clinical Research·2021· 49 citedOpen Access
Abstract 708: Limited release of circulating tumor DNA into the systemic circulation by peritoneal metastases from colorectal cancer
Cancer Research·2020· 3 cited
Concomitant intraperitoneal and systemic chemotherapy for extensive peritoneal metastases of colorectal origin: protocol of the multicentre, open-label, phase I, dose-escalation INTERACT trial
BMJ Open·2019· 24 citedOpen Access
Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC)
BMJ Open·2019· 30 citedOpen Access
Organoids from colorectal peritoneal metastases as a platform for improving hyperthermic intraperitoneal chemotherapy
British journal of surgery·2019· 105 citedOpen Access
Plasma Lp‐PLA<sub>2</sub> mass and apoB‐lipoproteins that carry Lp‐PLA<sub>2</sub> decrease after sodium
European Journal of Clinical Investigation·2012· 6 citedOpen Access
Simvastatin but not bezafibrate decreases plasma lipoprotein-associated phospholipase A2 mass in type 2 diabetes mellitus: Relevance of high sensitive C-reactive protein, lipoprotein profile and low-density lipoprotein (LDL) electronegativity
European Journal of Internal Medicine·2012· 12 cited
Plasma Lipoprotein-associated Phospholipase A2 Is Inversely Correlated with Proprotein Convertase Subtilisin-kexin Type 9
Archives of Medical Research·2012· 9 cited
Carotid intima media thickness is associated with plasma lipoprotein-associated phospholipase A2 mass in nondiabetic subjects but not in patients with type 2 diabetes
European Journal of Clinical Investigation·2011· 20 cited
Plasma Cholesteryl Ester Transfer, But Not Cholesterol Esterification, Is Related to Lipoprotein-Associated Phospholipase A2: Possible Contribution to an Atherogenic Lipoprotein Profile
The Journal of Clinical Endocrinology & Metabolism·2011· 15 citedOpen Access

Frequent Co-authors

Onno Kranenburg(11), Emma C. E. Wassenaar(9), Ignace H. J. T. de Hingh(9), Koen P. Rovers(9), Robin J. Lurvink(7), Djamila Boerma(6), Clément J.R. Huysentruyt(6), Remond J.A. Fijneman(6), Simon W. Nienhuijs(5), Maarten J. Deenen(5), Sjoerd G. Elias(4), Inne H.M. Borel Rinkes(4), Iris van ’t Erve(4), Maartje Los(4), L. Joost van Pelt(4), Paulien Rauwerdink(4), René J. Wiezer(3), Pétur Snæbjörnsson(3), Joost Nederend(3), Geert-Jan Creemers(3)