William C. Wetsel

Duke University — United States

Neuroscience · Life Sciences

72h-index18.7kcitations309works3.12yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(72), Receptor Mechanisms and Signaling(68), Neurotransmitter Receptor Influence on Behavior(60), Neuropeptides and Animal Physiology(27), Hypothalamic control of reproductive hormones(20)

Publications308 total

Perinatal exposure to perfluoroalkyl substances impairs maternal care and induces depressive-like behavior in mice
Toxicological Sciences·2025
Structure based discovery of antipsychotic-like TAAR1 agonists
2025Open Access
Virtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators
Journal of Chemical Information and Modeling·2025Open Access
Hidden Bias: GPCR Polymorphisms and the Genomic Landscape of β-Arrestin Signaling
2025Open Access
Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain
Cell·2025· 17 cited
Two doses of Qβ virus like particle vaccines elicit protective antibodies against heroin and fentanyl
npj Vaccines·2025· 2 citedOpen Access
Combination of Haloperidol With UNC9994, β-arrestin-Biased Analog of Aripiprazole, Ameliorates Schizophrenia-Related Phenotypes Induced by NMDAR Deficit in Mice
The International Journal of Neuropsychopharmacology·2024· 1 citedOpen Access
A two-dose regimen of Qβ virus-like particle-based vaccines elicit protective antibodies against heroin and fentanyl
2024Open Access
Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions
Nature Communications·2024· 23 citedOpen Access
Presynaptic Rac1 in the hippocampus selectively regulates working memory
eLife·2024Open Access
Presynaptic Rac1 in the hippocampus selectively regulates working memory
eLife·2024· 4 citedOpen Access
Presynaptic Rac1 in the hippocampus selectively regulates working memory
2024· 1 citedOpen Access
Structure-based discovery of conformationally selective inhibitors of the serotonin transporter
UNC Libraries·2024Open Access
Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity
UNC Libraries·2024· 2 citedOpen Access
Characterization of NCGC1360 and NCGC1366 as Highly-Selective D2 Dopamine Receptor Antagonists and Lead Candidates for the Treatment of Neuropsychiatric Disorders
Journal of Pharmacology and Experimental Therapeutics·2024
Combination of Haloperidol with UNC9994, β-arrestin-biased analog of Aripiprazole, ameliorates schizophrenia-related phenotypes induced by NMDAR deficit in mice
2024· 1 citedOpen Access
Presynaptic Rac1 in the hippocampus selectively regulates working memory
2024· 1 citedOpen Access
Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists
Biomolecules·2023· 1 citedOpen Access
The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice
UNC Libraries·2023Open Access
The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice
Frontiers in Molecular Biosciences·2023· 21 citedOpen Access
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Frequent Co-authors

Ramona M. Rodriguiz(28), Marc G. Caron(13), Raul R. Gainetdinov(7), Bryan L. Roth(7), Richard J. Weinberg(5), Tatyana D. Sotnikova(4), Dipendra K. Aryal(4), Meng Chen(3), Vincent Setola(3), Xi‐Ping Huang(3), Maria F. Sassano(3), Jean‐Martin Beaulieu(3), Jian Jin(3), George J Augustine(3), Namsoo Kim(3), Henry H. Yin(3), Vladimir M. Pogorelov(3), Il Hwan Kim(3), Scott H. Soderling(3), Sara R. Jones(2)