Andrea Oeckinghaus

German Cancer Research Center — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index6.1kcitations37works1.22yr avg
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Research Topics

NF-κB Signaling Pathways(10), Protein Kinase Regulation and GTPase Signaling(8), Pancreatic and Hepatic Oncology Research(5), Immune Response and Inflammation(4), Cytokine Signaling Pathways and Interactions(4)

Publications36 total

Increased activity of PRMT5-MEP50 complex improves survival of chromosomally unstable cancer cells by increasing tolerance to protein aggregation and proteotoxicity
2025Open Access
Structure and mechanism of the RalGAP tumor suppressor complex
Nature Communications·2025Open Access
The GTPase κB-Ras is an essential subunit of the RalGAP tumor suppressor complex
Journal of Biological Chemistry·2025· 1 citedOpen Access
RalGAP complexes control secretion and primary cilia in pancreatic disease
Life Science Alliance·2025· 1 citedOpen Access
Abstract 63: Orai1 regulates collagen secretion in pancreatic stellate cells and is enriched in fibrotic cancer-associated fibroblasts in PDAC
Cancer Research·2025
Abstract 6926: Targeting plasma membrane KCa3.1 channels reduces tumor size and mitigates gemcitabine-induced fibrosis in a PDAC mouse model
Cancer Research·2025
A CNA-35-based high-throughput fibrosis assay reveals ORAI1 as a regulator of collagen release from pancreatic stellate cells
Matrix Biology·2024· 5 citedOpen Access
Structure and mechanism of the RalGAP tumor suppressor complex
2024· 1 citedOpen Access
κ<scp>B</scp>‐<scp>R</scp>as proteins are fast‐exchanging <scp>GTP</scp>ases and function via nucleotide‐independent binding of Ral <scp>GTP</scp>ase‐activating protein complexes
FEBS Letters·2024· 3 citedOpen Access
A pan-cancer analysis implicates human <i>NKIRAS1</i> as a tumor-suppressor gene
Proceedings of the National Academy of Sciences·2023· 9 citedOpen Access
Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer
JCI Insight·2023· 13 citedOpen Access
Five‐to‐Seven Carbon Glycols Severely Impair Bioenergetics and Metabolism of Aggressive Lung Cancer Cells
Advanced NanoBiomed Research·2022Open Access
Five‐to‐Seven Carbon Glycols Severely Impair Bioenergetics and Metabolism of Aggressive Lung Cancer Cells
Advanced NanoBiomed Research·2022· 3 citedOpen Access
Control of Expression of Key Cell Cycle Enzymes Drives Cell Line-Specific Functions of CDK7 in Human PDAC Cells
International Journal of Molecular Sciences·2022· 11 citedOpen Access
Impact of the Nuclear Envelope on Malignant Transformation, Motility, and Survival of Lung Cancer Cells
Advanced Science·2021· 18 citedOpen Access
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
Molecular Cell·2021· 53 citedOpen Access
The RAL signaling network: Cancer and beyond
International review of cell and molecular biology·2020· 33 cited
κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
Nature Communications·2020· 37 citedOpen Access
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer
Cancer Cell·2020· 154 citedOpen Access
Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
Structure·2020· 34 citedOpen Access
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Frequent Co-authors

Daniel Kümmel(13), Lisa Helene Apken(8), Sankar Ghosh(6), Zoltán Pethő(6), Daniel Krappmann(5), Michael Meisterernst(5), René Rasche(5), Esther Michalke(5), Jürgen Ruland(4), Stephanie Beel(4), Ilka Neumann(4), Albrecht Schwab(4), Uta Ferch(3), Stephan Kiontke(3), P. Kraft(3), George H. Gauss(3), Blake Wiedenheft(3), Mark Young(3), C. Martin Lawrence(3), Eva Wardelmann(3)