Thomas Klose

Northwestern University — United States

Environmental Science · Physical Sciences

45h-index6.5kcitations169works2.72yr avg
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Research Topics

Bacteriophages and microbial interactions(32), Mosquito-borne diseases and control(29), Black Holes and Theoretical Physics(27), Viral Infections and Vectors(21), Advanced MEMS and NEMS Technologies(13)

Publications169 total

In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism
Nature Communications·2026Open Access
Rational design and in vivo validation of capsid inhibitors for enterovirus D68
Nature Communications·2026Open Access
Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines
PLoS Pathogens·2026Open Access
Analysis of the heterogenous structural states of the hexameric ATPase PilU of the Type IV pili from <i>Vibrio cholerae</i>
2026Open Access
An unconventional HxD motif orchestrates coatomer-dependent coronavirus morphogenesis
2025Open Access
Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope
Nature Communications·2025· 1 citedOpen Access
Catalysis in Motion: Large-Scale Domain Alternation Enables Co(III)-C Bond Homolysis in Lysine 5,6-Aminomutase
2024Open Access
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia
Nature Structural & Molecular Biology·2024· 17 citedOpen Access
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
Nature Structural & Molecular Biology·2024· 8 citedOpen Access
Abstract 2272 Structure Determination of MO14 Enterovirus D68 Mutation
Journal of Biological Chemistry·2024Open Access
The 2.6 Å Structure of a Tulane Virus Variant with Minor Mutations Leading to Receptor Change
Biomolecules·2024· 4 citedOpen Access
Molecular mechanism for Tn7-like transposon recruitment by a type I-B CRISPR effector
Cell·2023· 27 citedOpen Access
Structure of Vibrio Phage XM1, a Simple Contractile DNA Injection Machine
Viruses·2023· 22 citedOpen Access
Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5
Antiviral Research·2023· 7 citedOpen Access
Structural and Mechanistic Basis for Gbetagamma-mediated Activation of Phosphoinositide 3-kinase-gamma
Journal of Pharmacology and Experimental Therapeutics·2023· 1 citedOpen Access
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
2023Open Access
Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ
2023· 1 citedOpen Access
Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies
Proceedings of the National Academy of Sciences·2023· 5 citedOpen Access
prM-reactive antibodies reveal a role for partially mature virions in dengue virus pathogenesis
Proceedings of the National Academy of Sciences·2023· 20 citedOpen Access
Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1
Nature Communications·2022· 34 citedOpen Access
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Frequent Co-authors

Michael G. Rossmann(28), Richard Kühn(10), Bernard La Scola(6), Andrew S. Miller(6), Wen Jiang(6), James E. Crowe(6), Philippe Colson(5), Didier Raoult(5), Feng Long(5), Michael Diamond(5), Madhumati Sevvana(5), Geeta Buda(4), S. Saif Hasan(4), Andrei Fokine(4), Xinzheng Zhang(4), Tristan McLoughlin(4), Devika Sirohi(3), Lei Sun(3), Samia Benamar(3), Chun-Liang Chen(3)