Christine Des Rosiers

Montreal Heart Institute — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index7.4kcitations210works3.12yr avg
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Research Topics

Mitochondrial Function and Pathology(48), Metabolism and Genetic Disorders(45), Metabolomics and Mass Spectrometry Studies(34), Cardiovascular Function and Risk Factors(28), Adipose Tissue and Metabolism(28)

Publications207 total

Correlation of plasma lipidomic profiles with cardiometabolic disease in transfusion-dependent thalassemia patients with six-month N-acetylcysteine intervention: A prospective cohort study
Clinical Biochemistry·2025Open Access
An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress
Circulation·2025· 10 citedOpen Access
Insights into heart failure metabolite markers through explainable machine learning
Computational and Structural Biotechnology Journal·2025Open Access
Insights into Heart Failure Metabolite Markers through Explainable Machine Learning
2024Open Access
Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research project
EBioMedicine·2024· 14 citedOpen Access
The platelet lipidome is critically altered during septic shock
Archives of cardiovascular diseases·2024
Untargeted lipidomics to identify characteristic signatures and mechanisms of mitochondrial diseases according to genetic origin
Physiology·2024
EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors
2024· 1 citedOpen Access
Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results
iScience·2023· 3 citedOpen Access
A NRF2/β3-adrenoreceptor axis drives a sustained antioxidant and metabolic rewiring through the pentose-phosphate pathway to alleviate cardiac stress
2023Open Access
Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia
The FASEB Journal·2023· 1 citedOpen Access
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
Biology Direct·2023· 3 citedOpen Access
Remodeling of lipid landscape in high fat fed very-long chain acyl-CoA dehydrogenase null mice favors pro-arrhythmic polyunsaturated fatty acids and their downstream metabolites
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2023· 8 citedOpen Access
Linking platelet lipidome and inflammatory response in septic patients
Archives of Cardiovascular Diseases Supplements·2023· 1 cited
Phenomapping Of Patients With HFpEF Using Unsupervised Learning Analyses
Journal of Cardiac Failure·2023
Gene-metabolite annotation with shortest reactional distance enhances metabolite genome-wide association studies results
2023· 2 citedOpen Access
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
2023Open Access
Serum Lipidomic Screen Identifies Key Metabolites, Pathways, and Disease Classifiers in Crohn’s Disease
Inflammatory Bowel Diseases·2023· 24 citedOpen Access
Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation
Science·2023· 155 cited
Additional file 3 of Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism
Figshare·2023Open Access
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Frequent Co-authors

Henri Brunengraber(11), Bertrand Bouchard(9), Blandine Comte(8), William C. Stanley(7), Caroline Daneault(6), Guy Charron(6), France David(5), Bruce G. Allen(5), John C. Chatham(5), Roselle Gélinas(4), Benjamin Lauzier(4), Jason R.B. Dyck(4), Basil J. Petrof(4), F. Labarthe(4), Jean‐Claude Tardif(4), Karen M. O’Shea(4), Ramzi J. Khairallah(4), Charles A. Fernandez(3), Vernon W. Dolinsky(3), Anik Forest(3)