Sergio A. Rodriguez‐Aponte

Io Therapeutics (United States) — United States

Medicine · Health Sciences

11h-index593citations34works25.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(16), Monoclonal and Polyclonal Antibodies Research(7), Viral gastroenteritis research and epidemiology(6), Animal Virus Infections Studies(6), Viral Infectious Diseases and Gene Expression in Insects(6)

Publications34 total

Engineered antibodies that stabilize drug-modified KRASG12C neoantigens enable selective and potent cross-HLA immunotherapy
Nature Communications·2025Open Access
Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in <i>Komagataella phaffii</i>
Biotechnology and Bioengineering·2024· 1 citedOpen Access
CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome
Microbial Cell Factories·2024· 3 citedOpen Access
Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract
Science Advances·2024· 8 citedOpen Access
CRISPR-Cas9 knockout screen informs efficient reduction of the <i>Komagataella phaffii</i> secretome
2024Open Access
Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies
Science·2024· 138 citedOpen Access
Large-Scale Purification and Characterization of Recombinant Receptor-Binding Domain (RBD) of SARS-CoV-2 Spike Protein Expressed in Yeast
Vaccines·2023· 8 citedOpen Access
Nanoalum formulations containing aluminum hydroxide and CpG 1018 adjuvants: the effect on stability and immunogenicity of a recombinant SARS-CoV-2 RBD antigen (Dataset)
2023Open Access
Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018TM Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen
Vaccines·2023· 10 citedOpen Access
SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice
Research Square (Research Square)·2023· 1 citedOpen Access
Abstract 3371: A DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies
Cancer Research·2023· 1 cited
Minimal purification method enables developability assessment of recombinant proteins
Biotechnology and Bioengineering·2023· 2 citedOpen Access
An intravenous DNA-binding priming agent protects cell-free DNA and improves the sensitivity of liquid biopsies
2023· 8 citedOpen Access
Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants
Vaccine·2022· 6 citedOpen Access
Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants
2022Open Access
Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii
Microbial Cell Factories·2022· 7 citedOpen Access
RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge
mSphere·2022· 15 citedOpen Access
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity
Science Translational Medicine·2022· 93 citedOpen Access
Steric accessibility of the <i>N</i> -terminus improves the titer and quality of recombinant proteins secreted from <i>Komagataella phaffii</i>
2022Open Access
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants (Datasets)
2022
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Frequent Co-authors

J. Christopher Love(32), Neil C. Dalvie(24), Christopher A. Naranjo(18), Ryan S. Johnston(14), Sangeeta B. Joshi(13), David B. Volkin(13), Ozan S. Kumru(10), Kerry R. Love(10), Andrew M. Biedermann(9), Laura E. Crowell(9), Charles A. Whittaker(9), Harry Kleanthous(9), Kawaljit Kaur(8), Mary Kate Tracey(8), Sakshi Bajoria(8), Dan H. Barouch(7), Harish Rao(7), Rakesh R. Lothe(7), Meghraj P. Rajurkar(7), Umesh Shaligram(7)