Christopher M. Yengo

Hershey (United States) — United States

Medicine · Health Sciences

31h-index3.0kcitations150works1.32yr avg
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Research Topics

Cardiomyopathy and Myosin Studies(115), Muscle Physiology and Disorders(56), Cardiovascular Effects of Exercise(56), Cellular Mechanics and Interactions(20), Force Microscopy Techniques and Applications(20)

Publications150 total

Cryo-EM Reveals How Cardiomyopathy Therapeutic Drugs Modulate the Myosin Motors of the Heart
2025· 1 citedOpen Access
“QuickStainer”: a rapid negative staining device for improved preservation of molecular structure
2025· 1 citedOpen Access
Early-Stage Alcoholic Cardiomyopathy Highlighted by Metabolic Remodeling, Oxidative Stress, and Cardiac Myosin Dysfunction in Male Rats
International Journal of Molecular Sciences·2025Open Access
Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia
Nature Communications·2025· 2 citedOpen Access
BPS2025 - Cardiac myosin 25-hep E525K mutated construct with mavacamten is stabilized by three blocked head subfragment-2 interactions
Biophysical Journal·2025· 2 cited
BPS2025 - A critical salt bridge between the relay helix and activation loop in beta-cardiac myosin coordinates actin activation of the power stroke and phosphate release
Biophysical Journal·2025
BPS2025 - Impact of magnesium and ionic strength reveals a role of crucial salt bridge in the motor domain of human cardiac myosin abolished by the E525K mutation
Biophysical Journal·2025
BPS2025 - A single molecule mechanical characterization of MYO3A
Biophysical Journal·2025
BPS2025 - Differential modulation of beta-cardiac myosin conformations by cardiomyopathy-associated mutations in the converter domain
Biophysical Journal·2025
BPS2025 - Mavacamten and omecamtiv mecarbil modulate the structure of the interacting-heads motif by inducing distinct subfragment-2 conformations
Biophysical Journal·2025
Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia
2024· 1 citedOpen Access
Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release
PNAS Nexus·2024· 5 citedOpen Access
Tail length and E525K dilated cardiomyopathy mutant alter human β-cardiac myosin super-relaxed state
The Journal of General Physiology·2024· 11 citedOpen Access
Using synthetic thick filaments made from DNA to model the regulation of β-cardiac myosin motility by cMyBP-C
Biophysical Journal·2024Open Access
Cardiomyopathy-associated mutations in the converter domain of beta-cardiac myosin differentially alter formation of the super relaxed state and interacting heads motif
Biophysical Journal·2024Open Access
Impact of chronic alcohol consumption on cardiac myosin function: Role of oxidative stress
Biophysical Journal·2024Open Access
A single-molecule characterization of load-dependent phosphate rebinding to myosin Va
Biophysical Journal·2024
Temperature-dependent FRET reveals uncoupling of the super-relaxed state and interacting heads motif
Biophysical Journal·2024· 1 citedOpen Access
Tail Length and E525K Dilated Cardiomyopathy Mutant Alter Human β-Cardiac Myosin Super-Relaxed State
2023Open Access
The dynamics of actin protrusions can be controlled by tip-localized myosin motors
Journal of Biological Chemistry·2023· 15 citedOpen Access
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Frequent Co-authors

William C. Unrath(9), Bechara Kachar(7), Manmeet H. Raval(7), Omar A. Quintero(7), H. Lee Sweeney(6), Wanjian Tang(6), Darshan V. Trivedi(6), Shobana K. Ananthanarayanan(5), Christopher L. Berger(5), Felipe T. Salles(4), Uri Manor(4), Judy E. Moore(4), Andrea C. Dosé(4), Anja M. Swenson(4), M’hamed Grati(4), David D. Thomas(4), Donald J. Jacobs(4), Laura K. Gunther(4), Runjia Cui(3), Arthur S. Rovner(3)