Lauren M.F. Merlo

Lankenau Institute for Medical Research — United States

Neuroscience · Life Sciences

16h-index3.0kcitations42works1.82yr avg
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Research Topics

Tryptophan and brain disorders(16), Immune Cell Function and Interaction(15), Esophageal Cancer Research and Treatment(9), Cancer Genomics and Diagnostics(7), T-cell and B-cell Immunology(5)

Publications42 total

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK
Molecular Metabolism·2025· 2 citedOpen Access
Autoimmune arthritis: Transgenic mouse models and methods
Methods in cell biology·2025
IDO2 Drives Autoantibody Production and Joint Inflammation in a Preclinical Model of Arthritis by Repressing Runx1 Function in B Cells
The Journal of Immunology·2024· 3 cited
IDO2 mediates inflammatory responses through both enzymatic and non-enzymatic mechanisms
The Journal of Immunology·2024· 1 cited
Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK
2024· 3 citedOpen Access
Data from A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma
2023Open Access
Perspective on This Article from A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma
2023Open Access
Perspective on This Article from A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma
2023Open Access
Data from A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma
2023Open Access
Impact of IDO1 and IDO2 on the B Cell Immune Response
Frontiers in Immunology·2022· 38 citedOpen Access
The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism
The Journal of Immunology·2021· 23 citedOpen Access
A distinct non-enzymatic role for Indoleamine-2,3-dioxygenase (IDO)2 vs. IDO1 in autoimmune arthritis
The Journal of Immunology·2021· 1 cited
The immunomodulating enzyme indoleamine 2,3-dioxygenase 2 (IDO2) as a target for therapy in autoimmune disease
The Journal of Immunology·2021· 1 cited
The enzymatic function of IDO2 is not required for its proinflammatory role in driving autoantibodies and disease in preclinical arthritis
The Journal of Immunology·2021
Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses
Frontiers in Immunology·2020· 115 citedOpen Access
Application of simultaneous selective pressures slows adaptation
Evolutionary Applications·2020· 7 citedOpen Access
Peptide vaccination directed against IDO1-expressing immune cells elicits CD8<sup>+</sup> and CD4<sup>+</sup> T-cell-mediated antitumor immunity and enhanced anti-PD1 responses
Journal for ImmunoTherapy of Cancer·2020· 46 citedOpen Access
B-Cell-Targeted 3DNA Nanotherapy Against Indoleamine 2,3-Dioxygenase 2 (IDO2) Ameliorates Autoimmune Arthritis in a Preclinical Model
Clinical Pathology·2020· 12 citedOpen Access
Corrigendum: IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
International Immunology·2019· 8 citedOpen Access
The role of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 2 (IDO2) in initiation, development, and treatment of autoimmune disorders
The Journal of Immunology·2017
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Frequent Co-authors

Laura Mandik‐Nayak(24), Carlo C. Maley(15), George C. Prendergast(13), James B. DuHadaway(12), Alexander J. Muller(11), Weidan Peng(8), Brian J. Reid(6), Richard Metz(6), Najaf A. Shah(6), Samantha Grabler(6), Elizabeth Pigott(5), Xiaohong Li(5), Patricia L. Blount(5), Thomas L. Vaughan(5), James D. Montgomery(5), Andrew L. Mellor(3), Kathleen Sprouffske(3), Kristin L. Gardiner(3), John W. Pepper(2), Courtney Smith(2)