Jeffrey J. Widrick

Boston Children's Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index6.9kcitations139works1.42yr avg
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Research Topics

Muscle Physiology and Disorders(71), Muscle activation and electromyography studies(31), Cardiomyopathy and Myosin Studies(19), Sports Performance and Training(14), Spaceflight effects on biology(14)

Publications138 total

Conditional Dmd ablation in muscle and brain causes profound effects on muscle function and neurobehavior
Communications Biology·2025· 2 citedOpen Access
Loss of adenylosuccinate synthetase 1 in mice recapitulates features of <i>ADSS1</i> myopathy
Human Molecular Genetics·2025· 1 citedOpen Access
Loss of adenylosuccinate synthetase 1 in mice recapitulates features of <i>ADSS1</i> myopathy
2025Open Access
Muscle-specific increased expression of <i>JAG1</i> improves the skeletal muscle phenotype in dystrophin-deficient mice
Proceedings of the National Academy of Sciences·2025Open Access
361PGene replacement therapy for ADSS1 myopathy: preclinical investigation in mice
Neuromuscular Disorders·2025
Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy
Skeletal Muscle·2025· 1 citedOpen Access
KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy <i>in vivo</i>
2025· 1 citedOpen Access
Muscle-specific increased expression of <i>JAG1</i> improves skeletal muscle phenotype in dystrophin-deficient mice.
2025· 2 citedOpen Access
Conditional <i>Dystrophin</i> ablation causes profound effects on muscle development, neurobehavior, and extracellular matrix pathways
2025· 1 citedOpen Access
High resolution kinematic approach for quantifying impaired mobility of dystrophic zebrafish larvae
2024· 6 citedOpen Access
<scp>DOCK3</scp> regulates normal skeletal muscle regeneration and glucose metabolism
The FASEB Journal·2023· 8 citedOpen Access
Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset
eLife·2023· 15 citedOpen Access
Optimizing assays of zebrafish larvae swimming performance for drug discovery
Expert Opinion on Drug Discovery·2023· 17 citedOpen Access
Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish
Scientific Reports·2023· 19 citedOpen Access
Author response: Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset
2023Open Access
DOCK3 regulates normal skeletal muscle regeneration and glucose metabolism
2023· 2 citedOpen Access
Dynamin-2 reduction rescues the skeletal myopathy of a SPEG-deficient mouse model
JCI Insight·2022· 11 citedOpen Access
miR-486 is essential for muscle function and suppresses a dystrophic transcriptome
Life Science Alliance·2022· 35 citedOpen Access
Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension Kosmas Kosmas <sup>1,2</sup> , Zoe Michael <sup>2,3</sup> , Fotios Spyropoulos <sup>1,2</sup> , Jeffrey Widrick <sup>2,4</sup> , Ravi Jasuja <sup>2</sup> , Aimilia Papathanasiou <sup>1,2</sup> , Helen Christou <sup>1,2</sup> <sup>1</sup> Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA <sup>2</sup> Harvard Medical School, Boston, MA 02215, USA <sup>3</sup> Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02215, USA <sup>4</sup> Department of Genetics, Boston Children’s Hospital, Boston, MA 02215, USA
The FASEB Journal·2022
Dynamic Regulation of Inter-Organelle Communication by Ubiquitylation Controls Skeletal Muscle Development and Disease Onset
SSRN Electronic Journal·2022· 2 citedOpen Access
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Frequent Co-authors

R. H. Fitts(17), D. L. Costill(11), Scott Trappe(10), J. G. Romatowski(7), Todd A. Trappe(7), Alan H. Beggs(6), James Bain(5), Danny A. Riley(5), Matthew S. Alexander(5), Julian E. Stelzer(4), Genri Kawahara(4), Louis M. Kunkel(4), Gianni F. Maddalozzo(4), K. M. Norenberg(3), Miloslav Karhánek(3), Todd C. Shoepe(3), Dena P. Garner(3), Joyce L. Thompson(3), Christine M. Snow(3), Mohammadsharif Tabebordbar(2)