Mark E. Hester

Nationwide Children's Hospital — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.8kcitations54works5.32yr avg
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Research Topics

Pluripotent Stem Cells Research(8), Alzheimer's disease research and treatments(6), CRISPR and Genetic Engineering(6), Amyotrophic Lateral Sclerosis Research(5), Neuroinflammation and Neurodegeneration Mechanisms(5)

Publications54 total

REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency (REMEDY) using allele specific CRISPR targeting and HDR enhancers
2025Open Access
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Nature Communications·2025· 5 citedOpen Access
CRISPR-Cas9-Mediated Correction of <i>TSC2</i> Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2
The CRISPR Journal·2024· 3 cited
Single-stranded DNA with internal base modifications mediates highly efficient knock-in in primary cells using CRISPR-Cas9
Nucleic Acids Research·2024· 5 citedOpen Access
273 Internal chemical modifications in ssDNA templates enable improved CFTR gene correction and primary airway cell modeling compared to end-modified ssDNA templates
Journal of Cystic Fibrosis·2024
Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy
UNC Libraries·2024Open Access
Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
Cell Reports·2024· 20 citedOpen Access
Patient-derived organoids recapitulate glioma-intrinsic immune program and progenitor populations of glioblastoma
PNAS Nexus·2024· 14 citedOpen Access
Single-Stranded DNA with Internal Base Modifications Mediates Highly Efficient Gene Insertion in Primary Cells
2024· 1 citedOpen Access
Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy
Nature Genetics·2023· 21 citedOpen Access
Interferome perturbation of human brain organoids induces progenitor and neuronal dysfunction seen in multiple sclerosis and autism (P2-3.015)
Neurology·2023
Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma
Cell Reports·2023· 63 citedOpen Access
Additional file 10 of Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Figshare·2023Open Access
Additional file 7 of Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Figshare·2023Open Access
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Acta Neuropathologica Communications·2022· 112 citedOpen Access
Newly identified disorder of copper metabolism caused by variants in <i>CTR1</i>, a high-affinity copper transporter
Human Molecular Genetics·2022· 38 citedOpen Access
Cerebral organoids containing an <i>AUTS2</i> missense variant model microcephaly
Brain·2022· 51 citedOpen Access
LGG-47. Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity During Malignant Progression in Glioma
Neuro-Oncology·2022Open Access
AUTS2 Syndrome: Molecular Mechanisms and Model Systems
Frontiers in Molecular Neuroscience·2022· 57 citedOpen Access
Cerebral Organoids Containing an <i>AUTS2</i> Missense Variant Model Microcephaly
2022· 2 citedOpen Access
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Frequent Co-authors

Brian K. Kaspar(10), Dominic Julian(10), Summer Fair(8), Hongjun Fu(7), Katherine E. Miller(6), Yuzhou Chang(5), Liangping Li(5), Cankun Wang(5), Cody Morrison(5), Qin Ma(5), Carlos J. Miranda(4), Meghan Rao(4), Annalisa M. Hartlaub(4), Ethan W. Hollingsworth(4), Nathalie L. Maitre(4), Diana Acosta(4), Thomas G. Beach(4), Elaine R. Mardis(4), Gongbo Guo(4), Meisam Naeimi Kararoudi(4)