Timothy K. Tippin

Chimerix (United States) — United States

Medicine · Health Sciences

10h-index624citations16works0.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(4), Protease and Inhibitor Mechanisms(4), Hormonal Regulation and Hypertension(4), Rheumatoid Arthritis Research and Therapies(3), Estrogen and related hormone effects(3)

Publications16 total

A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Dordaviprone
The Journal of Clinical Pharmacology·2025
Novel approaches to assess the efficacy and toxicity of intestinal absorption enhancers
Carolina Digital Repository (University of North Carolina at Chapel Hill)·2019· 1 citedOpen Access
Brincidofovir Is Not a Substrate for the Human Organic Anion Transporter 1: A Mechanistic Explanation for the Lack of Nephrotoxicity Observed in Clinical Studies
Therapeutic Drug Monitoring·2016· 70 citedOpen Access
Biorelevant Refinement of the Caco-2 Cell Culture Model to Assess Efficacy of Paracellular Permeability Enhancers
Journal of Pharmaceutical Sciences·2007· 15 cited
Orally Active Nonpeptide CCK-A Agonists
Kluwer Academic Publishers eBooks·2006· 7 cited
In Vitro absorption and secretory quotients: Practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates
Journal of Pharmaceutical Sciences·2004· 17 cited
P‐glycoprotein Influences the Brain Concentrations of Cetirizine (Zyrtec®), a Second‐Generation Non‐Sedating Antihistamine
Journal of Pharmaceutical Sciences·2003· 85 cited
CYP3A INDUCTION BY N-HYDROXYFORMAMIDE TUMOR NECROSIS FACTOR-α CONVERTING ENZYME/MATRIX METALLOPROTEINASE INHIBITORS: USE OF A PREGNANE X RECEPTOR ACTIVATION ASSAY AND PRIMARY HEPATOCYTE CULTURE FOR ASSESSING INDUCTION POTENTIAL IN HUMANS
Drug Metabolism and Disposition·2003· 8 cited
Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System
Molecular Endocrinology·2002· 206 citedOpen Access
Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.
Biochemical Pharmacology·2001· 28 cited
Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases.
PubMed·2001· 75 cited
Inhibition of Tumor Necrosis Factor-α (TNF-α) Production and Arthritis in the Rat by GW3333, a Dual Inhibitor of TNF-α-Converting Enzyme and Matrix Metalloproteinases
Journal of Pharmacology and Experimental Therapeutics·2001· 39 cited
N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1′ isobutyl substitution
Bioorganic & Medicinal Chemistry Letters·2001· 21 citedOpen Access
Screening And Design Of Tumor Necrosis Factor-
2000
Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3.beta.-Hydroxy-.DELTA.5-steroid Dehydrogenase/3-Keto-.DELTA.5-steroid Isomerase by 6-Azaandrost-4-en-3-ones: Optimization of the C17 Substituent
Journal of Medicinal Chemistry·1995· 47 citedOpen Access
ChemInform Abstract: 6‐Azasteroids: Potent Dual Inhibitors of Human Type 1 and 2 Steroid 5. alpha.‐Reductase.
ChemInform·1994· 5 cited

Frequent Co-authors

Marcia L. Moss(6), Robert Andrews(5), Darryl McDougald(5), J. David Becherer(5), James G. Conway(4), Kevin M. Hedeen(4), Michael H. Rabinowitz(4), Janet Warner(4), D. Mark Bickett(4), Virginia M. Boncek(3), Thomas A. Brodie(3), Kenneth W. Batchelor(3), H. Neal Bramson(3), J. Darren Stuart(3), Elizabeth J. Beaudet(3), Steven A. Kliewer(2), Joseph W. Polli(2), Joan E. Humphreys(2), Cosette J. Serabjit‐Singh(2), D. Bickett(2)