M. Jonathan Fray

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index898citations67works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(10), Asymmetric Synthesis and Catalysis(9), Synthetic Organic Chemistry Methods(9), Protease and Inhibitor Mechanisms(6), Oxidative Organic Chemistry Reactions(6)

Publications67 total

N-Ylide Mediated Synthesis and Resolution of a Chiral Pyrimidinyl Cyclopropane Carboxylic Acid
Organic Process Research & Development·2023· 1 cited
Regioselective Amidomethylation of 4-Chloro-3-fluoropyridine by Metalation and Minisci-Type Reactions
The Journal of Organic Chemistry·2020· 6 cited
Passing on the medicinal chemistry baton: training undergraduates to be industry-ready through research projects between the University of Nottingham and GlaxoSmithKline
Drug Discovery Today·2016· 11 cited
Relative Binding Affinities of Integrin Antagonists by Equilibrium Dialysis and Liquid Chromatography–Mass Spectrometry
ACS Medicinal Chemistry Letters·2014· 7 citedOpen Access
Structure Activity Relationships of α<sub>v</sub> Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents
ACS Medicinal Chemistry Letters·2014· 24 citedOpen Access
From cook to chef: Facilitating the transition from recipe-driven to open-ended research-based undergraduate chemistry lab activities
New Directions in the Teaching of Physical Sciences·2014· 3 citedOpen Access
From Cook to Chef: Facilitating the Transition from Recipe-driven to Open-ended Research-based Undergraduate Chemistry Lab Activities
New Directions in the Teaching of Physical Sciences·2014· 4 cited
Investigation of Epimer Formation in Amide-Coupling Reactions: An Experiment for Advanced Undergraduate Students
Journal of Chemical Education·2013· 14 citedOpen Access
A practical drug discovery project at the undergraduate level
Drug Discovery Today·2013· 14 citedOpen Access
A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core
Tetrahedron Letters·2011· 4 cited
Practical Synthesis of (1<i>s</i>,4<i>s</i>)-4-(Methylamino)-1′<i>H</i>-spiro[cyclohexane-1,3′-furo[3,4-<i>c</i>]pyridin]-1′-one
Organic Process Research & Development·2010· 1 cited
Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: Improving metabolic stability and reducing ion channel activity
Bioorganic & Medicinal Chemistry Letters·2010· 4 citedOpen Access
Synthesis of PF-1247324, a Na<sub>V</sub>1.8 Sodium ChannelModulator
Synfacts·2010
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration (vol 19, pg 5078, 2009)
UCL Discovery (University College London)·2010
[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions
Tetrahedron Letters·2009· 42 cited
Corrigendum to “N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration” [Bioorg. Med. Chem. Lett. 19 (2009) 5078]
Bioorganic & Medicinal Chemistry Letters·2009
Optimisation of Permanganate Oxidation and Suzuki−Miyaura Coupling Steps in the Synthesis of a Na<sub>v</sub>1.8 Sodium Channel Modulator
Organic Process Research & Development·2009· 21 cited
Unusual base‐catalyzed exchange in the synthesis of deuterated PF‐2413873a
Journal of Labelled Compounds and Radiopharmaceuticals·2009· 9 cited
N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration
Bioorganic & Medicinal Chemistry Letters·2009· 13 citedOpen Access
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships
Bioorganic & Medicinal Chemistry Letters·2009· 15 citedOpen Access
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Frequent Co-authors

Alan Stobie(10), Florian Wakenhut(9), Gavin A. Whitlock(9), Paul V. Fish(8), Gerwyn Bish(6), David J. Bull(5), M. J. PARRY(4), Eric J. Thomas(4), John P. Mathias(4), Carly L. Nichols(4), Yvonne M. Po‐Ba(4), Hayley Snow(4), Simon J. F. Macdonald(4), Kelvin Cooper(3), Kenneth Richardson(3), John Steele(3), Thomas McInally(3), Mark H. Stefaniak(3), Barry M. Trost(2), R. P. DICKINSON(2)