Mehdi Tafti

Centro Universitário Filadélfia — Brazil

Neuroscience · Life Sciences

60h-index13.9kcitations219works0.72yr avg
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Research Topics

Sleep and Wakefulness Research(154), Sleep and related disorders(97), Circadian rhythm and melatonin(62), Obstructive Sleep Apnea Research(32), Neuroscience and Neuropharmacology Research(20)

Publications218 total

Normalization of network activity in an epilepsy model with a constitutively active <i>GABBR2</i> variant
Brain·2025Open Access
Contrasting contribution of resident and repopulated brain macrophages in sustaining sleep-wake circuitry
Communications Biology·2025· 2 citedOpen Access
Divergent modulation of dopaminergic neurons by hypocretin/orexin receptors-1 and -2 shapes dopaminergic cell activity and socio-emotional behavior
2025Open Access
Solriamfetol enhances alertness and cognitive performance in mice
2025Open Access
Monoallelic de novo <i>AJAP1</i> loss-of-function variants disrupt trans-synaptic control of neurotransmitter release
Science Advances·2024· 2 citedOpen Access
The paradox of REM sleep: Seven decades of evolution
Sleep Medicine Reviews·2024
Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control
Molecular Psychiatry·2023· 7 citedOpen Access
Hypothalamic control of noradrenergic neurons stabilizes sleep
2023· 7 citedOpen Access
Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control
2023· 2 citedOpen Access
Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy
Proceedings of the National Academy of Sciences·2023· 56 citedOpen Access
The evolutionarily conserved miRNA-137 targets the neuropeptide hypocretin/orexin and modulates the wake to sleep ratio
Proceedings of the National Academy of Sciences·2022· 31 citedOpen Access
LMOD3 gene variant in familial periodic hypersomnolence
Sleep Medicine·2022· 8 citedOpen Access
Orexin action on the dopaminergic system modulates theta during REM sleep and wakefulness
2022· 1 citedOpen Access
Narcolepsy with cataplexy is caused by epigenetic silencing of hypocretin neurons
2021· 9 cited
Neurobiology of cataplexy
Sleep Medicine Reviews·2021· 16 cited
The Swiss Primary Hypersomnolence and Narcolepsy Cohort study (SPHYNCS): Study protocol for a prospective, multicentre cohort observational study
Journal of Sleep Research·2021· 21 citedOpen Access
Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
Nature Communications·2020· 22 citedOpen Access
Kleine‐Levin syndrome is associated with <scp>LMOD</scp>3 variants
Journal of Sleep Research·2020· 4 citedOpen Access
Sleep as a default state of cortical and subcortical networks
Current Opinion in Physiology·2019· 19 citedOpen Access
REM sleep and cataplexy regulation in hcrt and serotonin transporter knockout mice
Sleep Medicine·2019
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Frequent Co-authors

Yves Dauvilliers(17), Paul Franken(15), Raphaël Heinzer(10), José Haba‐Rubio(9), Claudio L. Bassetti(9), Michel Lecendreux(9), Péter Vollenweider(7), Gert Jan Lammers(7), Geert Mayer(7), Zoltán Kutalik(7), Gérard Waeber(6), Ramin Khatami(6), Corinne Pfister(6), Michel Billiard(6), Pedro Marques‐Vidal(5), Martin Preisig(5), Stéphanie Maret(5), Brice Petit(5), Johannes Mathis(5), Hyun Hor(5)