Sanju Narayanan

RTI International — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index534citations33works0.02yr avg
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Research Topics

Pharmacological Receptor Mechanisms and Effects(12), Receptor Mechanisms and Signaling(10), Apelin-related biomedical research(8), Neuropeptides and Animal Physiology(6), Nuclear Receptors and Signaling(6)

Publications33 total

Development of Central Nervous System-Penetrant Apelin Receptor Agonists
Journal of Medicinal Chemistry·2025
RECENT ADVANCES IN THE DEVELOPMENT OF SMALL-MOLECULE APELIN RECEPTOR AGONISTS FOR CARDIOVASCULAR AND METABOLIC DISEASES
Medicinal chemistry reviews·2022· 1 cited
Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor
Bioorganic & Medicinal Chemistry·2022· 7 citedOpen Access
Synthesis and Characterization of an Orally Bioavailable Small Molecule Agonist of the Apelin Receptor
SSRN Electronic Journal·2022Open Access
Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice
Journal of Medicinal Chemistry·2021· 10 citedOpen Access
CCDC 1946461: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
CCDC 1946460: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
Identification of potent pyrazole based APELIN receptor (APJ) agonists
Bioorganic & Medicinal Chemistry·2019· 16 citedOpen Access
Identification of Potent Pyrazole‐Based Biased Small Molecule APJ Receptor Agonists
The FASEB Journal·2019
Discovery of a novel small molecule agonist scaffold for the APJ receptor
Bioorganic & Medicinal Chemistry·2016· 29 citedOpen Access
Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists
Journal of Pharmacology and Experimental Therapeutics·2016· 28 citedOpen Access
CCDC 1048741: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery
Journal of Medicinal Chemistry·2015· 46 citedOpen Access
Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series
Bioorganic & Medicinal Chemistry Letters·2015· 13 citedOpen Access
Discovery of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists
Bioorganic & Medicinal Chemistry Letters·2014· 9 citedOpen Access
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2
Bioorganic & Medicinal Chemistry Letters·2014· 5 citedOpen Access
Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists
Bioorganic & Medicinal Chemistry Letters·2014· 11 citedOpen Access
The dopamine uptake inhibitor, WIN 35,428, has sigma2 receptor agonist effects that contribute to its self‐administration (848.10)
The FASEB Journal·2014
Sigma receptor ligands attenuate methamphetamine‐induced hyperthermia but do not modulate IL‐1B mRNA expression in select brain regions
The FASEB Journal·2012
Sigma Receptors and Cocaine Abuse
Current Topics in Medicinal Chemistry·2011· 39 cited
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Frequent Co-authors

Scott P. Runyon(13), Christopher R. McCurdy(11), Vineetha Vasukuttan(10), Christophe Mésangeau(9), Rangan Maitra(9), Rae R. Matsumoto(5), Theresa Kopajtic(4), Jacques H. Poupaert(4), Debnath Bhuniya(4), Sudarshan Rajagopal(4), Takato Hiranita(3), Jonathan L. Katz(3), Nidhi Kaushal(3), James B. Thomas(3), Keith R. Warner(3), Sangdon Han(3), Dawei Yue(3), David J. Unett(3), Michael Morgan(3), Abu Sadeque(3)