Basil P. Hubbard

Medicine · Health Sciences

24h-index7.3kcitations63works2.62yr avg
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Research Topics

Sirtuins and Resveratrol in Medicine(26), CRISPR and Genetic Engineering(11), Autophagy in Disease and Therapy(9), Advanced biosensing and bioanalysis techniques(7), RNA and protein synthesis mechanisms(7)

Publications63 total

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks
Cell Reports·2026Open Access
CRISPR/Cas technologies for cancer drug discovery and treatment
Trends in Pharmacological Sciences·2025· 10 cited
Author response for "Identification of acrylamide-based covalent inhibitors of SARS-CoV-2 (SCoV-2) Nsp15 using high-throughput screening and machine learning"
2025
A Reverse Transcription Nucleic-Acid-Based Barcoding System for <i>In Vivo</i> Measurement of Lipid Nanoparticle mRNA Delivery
ACS Bio & Med Chem Au·2025· 2 citedOpen Access
Identification of acrylamide-based covalent inhibitors of SARS-CoV-2 (SCoV-2) Nsp15 using high-throughput screening and machine learning
RSC Advances·2025Open Access
Correction: Identification of acrylamide-based covalent inhibitors of SARS-CoV-2 (SCoV-2) Nsp15 using high-throughput screening and machine learning
RSC Advances·2025Open Access
Author response for "Identification of acrylamide-based covalent inhibitors of SARS-CoV-2 (SCoV-2) Nsp15 using high-throughput screening and machine learning"
2024
Development of a Novel HEK293 Cell Model Lacking SLC29A1 to Study the Pharmacology of Endogenous SLC29A2-Encoded Equilibrative Nucleoside Transporter Subtype 2
Drug Metabolism and Disposition·2024· 2 citedOpen Access
Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition
Journal of Translational Medicine·2024· 11 citedOpen Access
Abstract CT194: N-myristoylation inhibitor zelenirstat: New mechanistic insights and efficacy signals from a first in human phase I study
Cancer Research·2024· 1 cited
<scp>MMP</scp>‐2 regulates Src activation via repression of the <scp>CHK</scp>/<scp>MATK</scp> tumor suppressor in osteosarcoma
Cancer Reports·2023· 7 citedOpen Access
Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease
Journal of Biological Chemistry·2023· 12 citedOpen Access
MMP-2 regulates Src activation via repression of the CHK/MATK tumor suppressor in Osteosarcoma
2023Open Access
Siglec-6 mediates the uptake of extracellular vesicles through a noncanonical glycolipid binding pocket
Nature Communications·2023· 38 citedOpen Access
Abstract 1662: Understanding the sensitivity of cancer cells to myristoylation inhibitors for oncology applications
Cancer Research·2023· 1 cited
CRISPR-Click Enables Dual-Gene Editing with Modular Synthetic sgRNAs
Bioconjugate Chemistry·2022· 5 cited
Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences
Nature Communications·2022· 45 citedOpen Access
A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer
Cell Reports·2022· 11 citedOpen Access
Lipid phosphate phosphatase-2 promotes tumor growth through increased c-Myc expression
Theranostics·2022· 17 citedOpen Access
CRISPR-Click Enables Multi-Gene Editing with Modular Synthetic sgRNAs
2021Open Access
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Frequent Co-authors

David Sinclair(18), Christopher R. Cromwell(17), Khushwant S. Bhullar(7), Evan Kerek(7), James L. Ellis(6), Rafael de Cabo(5), Ana P. Gomes(5), Nathan L. Price(4), Alvin J. Y. Ling(4), Alejandro Martín‐Montalvo(4), Anabela P. Rolo(4), Vilhelm A. Bohr(4), George P. Vlasuk(4), Amanda R. Krysler(4), Juan Jovel(4), Olivier Julien(4), João S. Teodoro(3), Carlos M. Palmeira(3), Joseph A. Baur(3), Evi M. Mercken(3)