Anna Pasieka

Jagiellonian University — Poland

Medicine · Health Sciences

12h-index455citations21works1.32yr avg
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Research Topics

Cholinesterase and Neurodegenerative Diseases(18), Computational Drug Discovery Methods(16), Alzheimer's disease research and treatments(7), Phosphodiesterase function and regulation(4), Chemical synthesis and alkaloids(4)

Publications21 total

Overcoming the Challenges of Multi‐Target‐Directed Ligands for Alzheimer's Disease
2024Open Access
Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
Angewandte Chemie International Edition·2024· 4 citedOpen Access
Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
Angewandte Chemie·2024Open Access
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease
European Journal of Medicinal Chemistry·2023· 11 citedOpen Access
Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists?
ChemMedChem·2023· 35 citedOpen Access
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease
Bioorganic & Medicinal Chemistry·2023· 10 citedOpen Access
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies
European Journal of Medicinal Chemistry·2023· 14 citedOpen Access
Novel Drug-Like Fluorenyl Derivatives as Selective Butyrylcholinesterase and Β-Amyloid Inhibitors for the Treatment of Alzheimer's Disease
SSRN Electronic Journal·2023· 1 citedOpen Access
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau
European Journal of Medicinal Chemistry·2021· 23 citedOpen Access
Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended <i>In Cellulo</i>, <i>In Silico</i>, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
ACS Chemical Neuroscience·2021· 71 citedOpen Access
Discovery of multifunctional anti-Alzheimer’s agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters
European Journal of Medicinal Chemistry·2021· 21 citedOpen Access
Multifunctional Ligand Approach: Search for Effective Therapy Against Alzheimer’s Disease
Exon Publications eBooks·2020· 4 citedOpen Access
Crystal structure of human Butyrylcholinesterase in complex with N-((2S,3R)-4-((2,2-dimethylpropyl)amino)-3-hydroxy-1-phenylbutan-2-yl)-2,2-diphenylacetamide
2020
Multidirectional <i>in vitro</i> and <i>in cellulo</i> studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease
Journal of Enzyme Inhibition and Medicinal Chemistry·2020· 17 citedOpen Access
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease
European Journal of Medicinal Chemistry·2019· 55 citedOpen Access
MOLECULAR MODELING IN SEARCH OF NEW, MULTI-TARGET LIGANDS AGAINST ALZHEIMER'S DISEASE. EXPLORING THE BIOCHEMICAL MULTIVERSE.
MMSL·2018
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents
Molecules·2018· 45 citedOpen Access
Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents
ACS Chemical Neuroscience·2018· 54 citedOpen Access
Advances Toward Multifunctional Cholinesterase and β-Amyloid Aggregation Inhibitors
Future Medicinal Chemistry·2017· 31 citedOpen Access
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
Molecules·2016· 36 citedOpen Access
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Frequent Co-authors

Dawid Panek(18), Barbara Malawska(17), Anna Więckowska(15), Justyna Godyń(11), Raimon Sabaté(9), Jakub Jończyk(8), Gniewomir Latacz(8), Marek Bajda(7), Tomasz Wichur(7), Damijan Knez(7), Stanislav Gobec(7), Paula Zaręba(7), Xavier Brazzolotto(6), Jan Korábečný(5), Georg Höfner(5), Klaus T. Wanner(5), Natalia Szałaj(4), Alba Espargaró(4), Fabien Chantegreil(4), Kinga Sałat(4)