Nigel Sharfe

University of Toronto — Canada

Immunology and Microbiology · Life Sciences

21h-index2.3kcitations46works0.32yr avg
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Research Topics

Immunodeficiency and Autoimmune Disorders(20), Immune Cell Function and Interaction(14), Axon Guidance and Neuronal Signaling(13), T-cell and B-cell Immunology(9), Ubiquitin and proteasome pathways(8)

Publications46 total

Autosomal-dominant Roquin-1 immunodeficiency and hyperinflammation
Journal of Allergy and Clinical Immunology·2025
Pre-T cell receptor-α immunodeficiency detected exclusively using whole genome sequencing
npj Genomic Medicine·2025· 1 citedOpen Access
Impact of the COVID-19 pandemic on patients with primary immunodeficiency
LymphoSign Journal·2024
Data from The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells
2023Open Access
Supplementary Figure 1 from The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells
2023Open Access
Supplementary Figure 1 from The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells
2023Open Access
Supplementary Figure 2 from The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells
2023Open Access
Data from The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells
2023Open Access
Supplementary Figure 2 from The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells
2023Open Access
Novel immunodeficiency caused by homozygous mutation in <i>SLC19A1</i> encoding the reduced folate carrier
Blood·2023· 1 citedOpen Access
NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity
Journal of Autoimmunity·2022· 18 citedOpen Access
Case Report: Eosinophilic Esophagitis in a Patient With a Novel STAT1 Gain-of-Function Pathogenic Variant
Frontiers in Immunology·2022· 10 citedOpen Access
Combined immunodeficiency caused by a novel homozygous NFKB1 mutation
Journal of Allergy and Clinical Immunology·2020· 19 cited
Defining the biological responses of IL-6 by the study of a novel IL-6 receptor chain immunodeficiency
Journal of Allergy and Clinical Immunology·2019· 38 citedOpen Access
Novel heterozygous <i>NFKB1</i> mutation—variable penetrance in a family cohort
LymphoSign Journal·2019Open Access
Two different STAT1 gain-of-function mutations lead to diverse IFN-γ-mediated gene expression
npj Genomic Medicine·2018· 17 citedOpen Access
Dual loss of p110δ PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features
Journal of Allergy and Clinical Immunology·2017· 29 citedOpen Access
Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11)
Journal of Allergy and Clinical Immunology·2017· 94 cited
CD40 DEFICIENCY: A UNIQUE ADULT PATIENT WITH HYPER IMMUNOGLOBULIN M SYNDROME AND NORMAL EXPRESSION OF CD40
LymphoSign Journal·2017· 8 citedOpen Access
The effects of STAT1 dysfunction on the gut
LymphoSign Journal·2016· 9 cited
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Frequent Co-authors

Chaim M. Roifman(37), Harjit Dadi(20), Andrew Freywald(15), Daniele Merico(9), Linda Vong(9), Amit Nahum(8), Luke Truitt(7), Tanya Freywald(7), John F. DeCoteau(7), Bo Ngan(6), Adi Ovadia(5), Jo-Anne Herbrick(4), Thomas Grünberger(4), Lorand Cimpean(4), David Chitayat(3), Ariana Karanxha(3), Amarilla B. Mandola(3), Peter Demin(3), O. B. Rounova(3), Michal Shahar(2)