Barrie W. Bycroft

University of Nottingham — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index12.8kcitations210works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(43), Microbial Natural Products and Biosynthesis(31), Bacterial biofilms and quorum sensing(30), Bacterial Genetics and Biotechnology(23), Antibiotic Resistance in Bacteria(19)

Publications210 total

Dissection of the promoter/operator region and evaluation of N-acylhomoserine lactone mediated transcriptional regulation of elastase expression in Pseudomonas aeruginosa
FEMS Microbiology Letters·2006· 12 citedOpen Access
Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosasignal molecule, N-(3-oxododecanoyl)-L-homoserine lactone
Acta Diabetologica·2005· 27 cited
Differential Immune Modulatory Activity of <i>Pseudomonas aeruginosa</i> Quorum-Sensing Signal Molecules
Infection and Immunity·2004· 178 citedOpen Access
Biosynthesis of Carbapenem Antibiotics: New Carbapenam Substrates for Carbapenem Synthase (CarC)
ChemBioChem·2004· 24 citedOpen Access
Expedient Synthesis of a Novel Class of Pseudoaromatic Amino Acids: Tetrahydroindazol‐3‐yl‐ and Tetrahydrobenzisoxazol‐3‐ylalanine Derivatives.
ChemInform·2004
CCDC 224296: Experimental Crystal Structure Determination
The Cambridge Structural Database·2004Open Access
Expedient synthesis of a novel class of pseudoaromatic amino acids: tetrahydroindazol-3-yl- and tetrahydrobenzisoxazol-3-ylalanine derivatives
Tetrahedron Letters·2003· 16 citedOpen Access
Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system
Bioorganic & Medicinal Chemistry Letters·2003· 49 cited
Bacterial quorum sensing signalling molecules as immune modulators
Cambridge University Press eBooks·2003· 6 cited
Bacterial quorum-sensing molecules: potential utility in the treatment of inflammatory skin disease.
British Journal of Dermatology·2003
Convenient syntheses of (3S,5S)-carbapenam-3-carboxylates and their biosynthetic relevance
Tetrahedron Letters·2003· 16 cited
Synthetic Analogues of the Bacterial Signal (Quorum Sensing) Molecule <i>N</i>-(3-Oxododecanoyl)-<scp>l</scp>-homoserine Lactone as Immune Modulators
Journal of Medicinal Chemistry·2002· 248 cited
QUORUM SENSING AND THE POPULATION-DEPENDENT CONTROL OF VIRULENCE
2001· 45 cited
Haemodynamic effects of the bacterial quorum sensing signal molecule, <i>N</i>‐(3‐oxododecanoyl)‐<scp>L</scp>‐homoserine lactone, in conscious, normal and endotoxaemic rats
British Journal of Pharmacology·2001· 44 citedOpen Access
Structure, activity and evolution of the group I thiolactone peptide quorum‐sensing system of<i>Staphylococcus aureus</i>
Molecular Microbiology·2001· 186 cited
DOES SULPHUR SUPPLY TO THE BULB AFFECT STORAGE OF ONIONS
Acta Horticulturae·2001· 5 cited
A Dde-based carboxy linker for solid-phase synthesis
Tetrahedron Letters·2001· 18 cited
Interaction of the Lantibiotic Nisin with Mixed Lipid Bilayers:  A <sup>31</sup>P and <sup>2</sup>H NMR Study
Biochemistry·2000· 80 cited
Quorum sensing and the population-dependent control of virulence
Philosophical Transactions of the Royal Society B Biological Sciences·2000· 254 citedOpen Access
N-acyl homoserine lactone binding to the CarR receptor determines quorum-sensing specificity in Erwinia
The EMBO Journal·2000· 175 citedOpen Access
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Frequent Co-authors

Paul Williams(29), Gordon S.A.B. Stewart(23), Siri Ram Chhabra(19), George P. C. Salmond(15), Weng C. Chan(14), Michael K. Winson(12), Nigel J. Bainton(9), Gordon C. K. Roberts(8), Miguel Cámara(7), Simon Swift(7), Philip J. Hill(5), Simon J. McGowan(5), Lu‐Yun Lian(5), Paul Stead(4), David Pritchard(4), Mavis Daykin(3), John Throup(3), Matthew T. G. Holden(3), Mohammed Sebaihia(3), H. M. Dodd(3)