Alan A. DiSpirito

Iowa State University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index7.7kcitations148works3.62yr avg
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Research Topics

Microbial metabolism and enzyme function(72), Metal-Catalyzed Oxygenation Mechanisms(31), Microbial bioremediation and biosurfactants(27), Porphyrin Metabolism and Disorders(16), Anaerobic Digestion and Biogas Production(15)

Publications148 total

Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents
Biomedicine & Pharmacotherapy·2025Open Access
Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by <sup>64</sup> Cu PET/MRI
British Journal of Pharmacology·2025· 1 citedOpen Access
Heterologous Biosynthesis of Methanobactin from <i>Methylocystis</i> sp. Strain SB2 in <i>Methylosinus trichosporium</i> OB3b
ACS Synthetic Biology·2024· 1 cited
Copper impairs the intestinal barrier integrity in Wilson disease
Metabolism·2024· 16 cited
Metal Sequestration by Extracellular Peptides
2024Open Access
MmoD regulates soluble methane monooxygenase and methanobactin production in <i>Methylosinus trichosporium</i> OB3b
Applied and Environmental Microbiology·2023· 12 citedOpen Access
Microbial Competition for Copper: Impacts on Carbon and Nitrogen Cycling
2023Open Access
Inhibition of nitrous oxide reduction in forest soil microcosms by different forms of methanobactin
Environmental Microbiology·2023· 5 citedOpen Access
ARBM-101 as an emerging potent therapeutic option for Wilson disease
Journal of Hepatology·2023
Crystal structure of MbnF: an NADPH-dependent flavin monooxygenase from <i>Methylocystis</i> strain SB2
Acta Crystallographica Section F Structural Biology Communications·2023· 4 citedOpen Access
Cu-64 as a tool in Wilson‘s disease research
Nuklearmedizin - NuclearMedicine·2023
ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson’s Disease Rats
Gastroenterology·2023· 34 citedOpen Access
Methanobactin: a copper binding compound having antibiotic and antioxidant activity isolated from methanotrophic bacteria
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2023· 5 citedOpen Access
Use of methanobactin
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)·2023Open Access
Multiple Mechanisms for Copper Uptake by Methylosinus trichosporium OB3b in the Presence of Heterologous Methanobactin
mBio·2022· 15 citedOpen Access
Diffusion of <scp> H <sub>2</sub> S </scp> from anaerobic thiolated ligand biodegradation rapidly generates bioavailable mercury
Environmental Microbiology·2022· 10 citedOpen Access
Variable Inhibition of Nitrous Oxide Reduction in Denitrifying Bacteria by Different Forms of Methanobactin
Applied and Environmental Microbiology·2022· 11 citedOpen Access
Two TonB-Dependent Transporters in Methylosinus trichosporium OB3b Are Responsible for Uptake of Different Forms of Methanobactin and Are Involved in the Canonical "Copper Switch".
PubMed·2022· 7 citedOpen Access
Two TonB-Dependent Transporters in Methylosinus trichosporium OB3b Are Responsible for Uptake of Different Forms of Methanobactin and Are Involved in the Canonical “Copper Switch”
Applied and Environmental Microbiology·2021· 12 citedOpen Access
Evidence for methanobactin “Theft” and novel chalkophore production in methanotrophs: impact on methanotrophic-mediated methylmercury degradation
The ISME Journal·2021· 33 citedOpen Access
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Frequent Co-authors

Jeremy D. Semrau(24), James A. Zahn(10), Stéphane Vuilleumier(7), Alan B. Hooper(6), Nathan Bandow(5), William E. Antholine(5), J. Colin Murrell(5), Dongwon Choi(5), Scott C. Hartsel(5), Sukhwan Yoon(4), Jerry L. Hatfield(3), Hans Zischka(3), Josef Lichtmannegger(3), Ryan C. Kunz(3), Eric S. Boyd(3), Arlene M. de la Mora(3), Bipin S. Baral(3), Warren H. Gallagher(3), Wenyu Gu(3), Mark S. Hargrove(3)