Luis E.F. Almeida

National Institutes of Health Clinical Center — United States

Medicine · Health Sciences

16h-index968citations36works2.02yr avg
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Research Topics

Hemoglobinopathies and Related Disorders(24), Erythrocyte Function and Pathophysiology(14), Iron Metabolism and Disorders(10), Nicotinic Acetylcholine Receptors Study(7), Neuroscience and Neuropharmacology Research(4)

Publications36 total

Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice
JCI Insight·2026Open Access
Metabolic stimulation improves bioenergetics and haematologic indices of circulating erythrocytes from sickle cell mice
The Journal of Physiology·2025· 2 citedOpen Access
Syk inhibition suppresses NLRP3 inflammasome activation in platelets from sickle cell mice leading to decreased platelet secretion, aggregation, spreading, and in vitro thrombus formation
Thrombosis Research·2024· 4 citedOpen Access
NLRP3 Inflammasome-Mediated Platelet Activation and Thrombus Formation in Sickle Cell Mice Can be Targeted By the BTK Inhibitor Ibrutinib
Blood·2023· 3 cited
Calcium flux alterations in erythrocytes from sickle cell mice: The relevance of mean corpuscular volume
Blood Cells Molecules and Diseases·2023· 3 citedOpen Access
Mouse models of sickle cell disease: Imperfect and yet very informative
Blood Cells Molecules and Diseases·2023· 23 citedOpen Access
Nitrite decreases sickle hemoglobin polymerization in vitro independently of methemoglobin formation
Toxicology and Applied Pharmacology·2023· 3 citedOpen Access
Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model
Blood Cells Molecules and Diseases·2022· 32 citedOpen Access
NLRP3 inflammasome and bruton tyrosine kinase inhibition interferes with upregulated platelet aggregation and in vitro thrombus formation in sickle cell mice
Biochemical and Biophysical Research Communications·2021· 18 citedOpen Access
Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease
Blood·2021· 114 citedOpen Access
Nitric oxide and sickle cell disease—Is there a painful connection?
Experimental Biology and Medicine·2020· 13 citedOpen Access
Sickle cell disease mice have cerebral oxidative stress and vascular and white matter abnormalities
Blood Cells Molecules and Diseases·2020· 9 citedOpen Access
Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum
Brain Research·2020· 7 citedOpen Access
Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments
Nitric Oxide·2019· 17 citedOpen Access
The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice
Nitric Oxide·2018· 7 cited
The corticosteroid compounds prednisolone and vamorolone do not alter the nociception phenotype and exacerbate liver injury in sickle cell mice
Scientific Reports·2018· 13 citedOpen Access
RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice
Haematologica·2018· 16 citedOpen Access
The NLRP3 Inflammasome in Platelets Is Upregulated in Sickle Cell Disease and Promotes Platelet Aggregation and In Vitro Thrombosis
Blood·2017· 1 cited
Blood collection vials and clinically used intravenous fluids contain significant amounts of nitrite
Free Radical Biology and Medicine·2017· 8 cited
Antisense Oligonucleotide Against Kelch-like Ech-Associated protein1 Ameliorates Liver Injury in Sickle Cell Mice
Blood·2016· 1 cited
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Frequent Co-authors

Zenaide Quezado(28), Sayuri Kamimura(21), Meghann L. Smith(13), Li Wang(11), Alfia Khaibullina(10), Sebastian Vogel(10), Martha Quezado(6), Edna F. R. Pereira(5), Christian A. Combs(5), Swee Lay Thein(5), Celia M. de Souza Batista(5), Paul Wakim(5), William R. Randall(4), Edson X. Albuquerque(4), Nicholas Spornick(4), Nicholas J. Kenyon(4), Mehdi Nouraie(4), Sarah Albani(4), Julia C. Finkel(4), Patricia M. Zerfas(4)