Richard Heath

Newcastle University — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index4.6kcitations22works0.02yr avg
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Research Topics

Metabolism, Diabetes, and Cancer(11), Pancreatic function and diabetes(9), Calcium signaling and nucleotide metabolism(4), Natural Antidiabetic Agents Studies(3), Advanced Chemical Physics Studies(2)

Publications22 total

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
Scientific Reports·2023· 12 citedOpen Access
Structural basis of AMPK regulation by small molecule activators
Nature Communications·2013· 530 citedOpen Access
Structure of full length human AMPK in complex with a small molecule activator, a thienopyridone derivative (A-769662)
2013
ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase
Cell Metabolism·2011· 166 citedOpen Access
5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes
Bioscience Reports·2011· 11 cited
Structure of mammalian AMPK and its regulation by ADP
Nature·2011· 906 citedOpen Access
Structure of an active form of mammalian AMPK
2011
Structure of the regulatory fragment of mammalian aMPK in complex with two ADP
2011
Structural basis for AMP binding to mammalian AMP-activated protein kinase
Nature·2007· 574 cited
Defining the Mechanism of Activation of AMP-activated Protein Kinase by the Small Molecule A-769662, a Member of the Thienopyridone Family
Journal of Biological Chemistry·2007· 343 citedOpen Access
Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP
2007
Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state
American Journal of Physiology-Endocrinology and Metabolism·2006· 61 cited
Insulin Antagonizes Ischemia-induced Thr 172 Phosphorylation of AMP-activated Protein Kinase -Subunits
2006
Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491
Journal of Biological Chemistry·2005· 337 citedOpen Access
Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
Cell Metabolism·2005· 1.4k citedOpen Access
Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period
Journal of Lipid Research·2003· 151 citedOpen Access
Tuning the Singlet−Triplet Energy Gap in a Non-Kekulé Series by Designed Structural Variation. The Singlet States of <i>N</i>-Substituted-3,4-dimethylenepyrrole Biradicals
Journal of the American Chemical Society·1997· 33 cited
ChemInform Abstract: Absolute Rates of Heterocyclic Singlet Biradical Reactions Determined by Nanosecond Time‐Resolved Absorption Spectroscopy. Dimerizations and Cycloadditions to Alkenes and to Dioxygen
ChemInform·1994
Absolute rates of heterocyclic singlet biradical reactions determined by nanosecond time-resolved absorption spectroscopy. Dimerizations and cycloadditions to alkenes and to dioxygen
The Journal of Physical Chemistry·1993· 18 cited
Long-lived spin isomerism of singlet and triplet states of N-arenesulfonyl-3,4-dimethylenepyrroles
Journal of the American Chemical Society·1993· 34 cited
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Frequent Co-authors

David Carling(13), P.A. Walker(8), L.F. Haire(8), S.J. Gamblin(8), Bing Xiao(7), E. Underwood(6), David Carmena(6), John F. Eccleston(5), Peter Saiu(5), Matthew J. Sanders(4), Faith V. Mayer(4), Chun Jing(4), Stephen R. Martin(4), Jerome A. Berson(4), S.R. Martin(4), Steven Howell(3), Rein Aasland(3), Fiona C. Leiper(3), Linda C. Bush(3), Alain Berinstain(3)