Manabu Chokki

Teijin (Japan) — Japan

Medicine · Health Sciences

12h-index643citations21works0.02yr avg
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Research Topics

Vitamin D Research Studies(7), Click Chemistry and Applications(5), Fluorine in Organic Chemistry(4), Biotin and Related Studies(4), Vitamin C and Antioxidants Research(3)

Publications21 total

Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle
Molecular Metabolism·2013· 115 citedOpen Access
TEI-A00114: A new vitamin D3 analogue that inhibits neutrophil recruitment in an acute lung injury hamster model while showing reduced hypercalcemic activity
Steroids·2012· 4 cited
Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-α-induced IL-8 secretion in the human airway epithelial cell line NCI-H292
Life Sciences·2006· 41 cited
Human airway trypsin‐like protease induces amphiregulin release through a mechanism involving protease‐activated receptor‐2‐mediated ERK activation and TNF α‐converting enzyme activity in airway epithelial cells
FEBS Journal·2005· 52 citedOpen Access
Interleukin‐11 as an osteoprotegerin‐inducing factor in culture medium of blastic cells from a patient with acute megakaryocytic leukemia complicated with osteosclerosis
American Journal of Hematology·2004· 8 cited
Human Airway Trypsin-Like Protease Increases Mucin Gene Expression in Airway Epithelial Cells
American Journal of Respiratory Cell and Molecular Biology·2003· 101 cited
CCDC 174237: Experimental Crystal Structure Determination
The Cambridge Structural Database·2002Open Access
(23S)- and (23R)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1α,25-dihydroxyvitamin D3
Steroids·2001· 24 cited
Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1α,25-dihydroxyvitamin D3 and 20-epi-2-methyl-1α,25-dihydroxyvitamin D3
Steroids·2001· 14 cited
Antagonistic Actions<i>in Vivo</i>of (23S)-25-Dehydro-1α-Hydroxyvitamin D<sub>3-</sub>26,23-Lactone on Calcium Metabolism Induced by 1α,25-Dihydroxyvitamin D<sub>3</sub>
Endocrinology·2001· 30 cited
Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1,25-dihydroxyvitamin D<sub>3</sub> and Their 20-Epimers:  Unique Activity Profiles Depending on the Stereochemistry of the A-Ring and at C-20
Journal of Medicinal Chemistry·2000· 73 cited
Antagonistic Action of Novel 1α,25-Dihydroxyvitamin D3-26,23-Lactone Analogs on 25-Hydroxyvitamin-D3-24-hydroxylase Gene Expression Induced by 1α,25-Dihydroxy-vitamin D3 in Human Promyelocytic Leukemia (HL-60) Cells
Archives of Biochemistry and Biophysics·2000· 20 cited
ChemInform Abstract: Synthesis and Biological Activity of 2‐Methyl‐20‐epi Analogues of 1α,25‐Dihydroxyvitamin D<sub>3</sub>.
ChemInform·1998
Comparison of Cytotoxic Effects of Bisphosphonates In Vitro and In Vivo
Calcified Tissue International·1998· 37 cited
Synthesis and biological activity of 2-methyl-20-epi analogues of 1α,25-dihydroxyvitamin D3
Bioorganic & Medicinal Chemistry Letters·1998· 34 cited
ChemInform Abstract: A Novel and Practical Route to A‐Ring Enyne Synthon for 1α,25‐Dihydroxyvitamin D<sub>3</sub> Analogues: Synthesis of A‐Ring Diastereomers of 1α,25‐Dihydroxyvitamin D<sub>3</sub> and 2‐Methyl‐1,25‐dihydroxyvitamin D<sub>3</sub>.
ChemInform·1998
A novel and practical route to A-ring enyne synthon for 1α,25-dihydroxyvitamin D3 analogs: Synthesis of A-ring diastereomers of 1α,25-dihydroxyvitamin D3 and 2-methyl-1,25-dihydroxyvitamin D3
Bioorganic & Medicinal Chemistry Letters·1998· 66 cited
Effects of alendronate on plasma calcium levels, urinary calcium excretion, and bone resorption markers in normal rats: comparison with elcatonin, synthetic eel calcitonin.
Endocrinology·1996· 9 citedOpen Access
Antiallergic profile of the novel H1-antihistaminic compound levocabastine.
PubMed·1993· 9 cited
Effect of cAMP on the histamine release from rat peritoneal mast cells.
The Japanese Journal of Pharmacology·1993Open Access
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Frequent Co-authors

Seiichi Ishizuka(8), Toshie Fujishima(7), Daishiro Miura(7), Katsuhiro Konno(6), Hiroaki Takayama(6), Zhaopeng Liu(5), Hiroshi Eguchi(4), Takashi Kamimura(4), Shôjirô Maki(4), Hiroaki Mitsuhashi(3), Keiichi Ozono(3), Anthony W. Norman(3), Taihei Shirasaka(3), C. Wayne Smith(2), Hector F. DeLuca(2), Yoshiaki Azuma(2), Tomohiro Ohta(2), Mamoru Kiyoki(2), Mayuko Kurobe(2), Keiji Izushi(2)