S. KLUTCHKO

University of Auckland — New Zealand

Chemistry · Physical Sciences

17h-index1.6kcitations50works0.02yr avg
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Research Topics

Synthesis and Biological Evaluation(10), Synthesis of Organic Compounds(8), Synthesis and biological activity(7), Synthesis and Catalytic Reactions(7), Chemical Reaction Mechanisms(6)

Publications50 total

Tyrosine Kinase Inhibitors. 19. 6-Alkynamides of 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-<i>d</i>]pyrimidines as Irreversible Inhibitors of the erbB Family of Tyrosine Kinase Receptors
Journal of Medicinal Chemistry·2006· 79 citedOpen Access
Anti-Angiogenic Activity of Selected Receptor Tyrosine Kinase Inhibitors, PD166285 and PD173074: Implications for Combination Treatment with Photodynamic Therapy
Investigational New Drugs·1999· 96 cited
ChemInform Abstract: 2‐Substituted Aminopyrido[2,3‐d]pyrimidin‐7(8H)‐ones. Structure—Activity Relationships Against Selected Tyrosine Kinases and in vitro and in vivo Anticancer Activity.
ChemInform·1998· 2 cited
Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidines:  Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors
Journal of Medicinal Chemistry·1998· 84 citedOpen Access
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
PubMed·1998· 6 cited
2-Substituted Aminopyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity
Journal of Medicinal Chemistry·1998· 130 citedOpen Access
In Vitro Pharmacological Characterization of PD 166285, a New Nanomolar Potent and Broadly Active Protein Tyrosine Kinase Inhibitor
Journal of Pharmacology and Experimental Therapeutics·1997· 94 cited
ChemInform Abstract: Benzofuran Derivatives as ETA‐Selective, Non‐Peptide Endothelin Antagonists.
ChemInform·1997
ChemInform Abstract: Synthesis and Structure‐Activity Relationships of 9‐Substituted Acridines as Endothelin‐A Receptor Antagonists.
ChemInform·1997
Benzofuran derivatives as ETA-selective, non-peptide endothelin antagonists
European Journal of Medicinal Chemistry·1997· 17 cited
Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists
Bioorganic & Medicinal Chemistry Letters·1996· 17 cited
ChemInform Abstract: Derivatives of 5‐((1‐(4′‐Carboxybenzyl)imidazolyl)methylidene) hydantoins as Orally Active Angiotensin II Receptor Antagonists.
ChemInform·1996· 2 cited
Derivatives of 5-[[1-4(4-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists
Journal of Medicinal Chemistry·1995· 25 citedOpen Access
ChemInform Abstract: Tetrahydroisoquinoline Derivatives with AT2‐Specific Angiotensin II Receptor Binding Inhibitory Activity.
ChemInform·1994· 2 cited
Tetrahydroisoquinoline derivatives with AT2-specific angiotensin II reception binding inhibitory activity
Bioorganic & Medicinal Chemistry Letters·1994· 16 cited
Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation
Journal of Medicinal Chemistry·1993· 20 citedOpen Access
ChemInform Abstract: Synthesis of Amino 1,3‐Diols, e.g. (V) ‐ (VIII). Ring Opening of N‐ Acyl Activated Lactams, e.g. (I), with Carbon Nucleophiles, e.g. (II), (XI).
ChemInform·1993
Synthesis of Amino 1,3-Diols. Ring Opening of N-Acyl Activated Lactams with Carbon Nucleophiles
Synthetic Communications·1993· 2 cited
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors
Journal of Medicinal Chemistry·1992· 371 citedOpen Access
Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype
Journal of Medicinal Chemistry·1991· 161 citedOpen Access
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Frequent Co-authors

John Shavel(14), M. Von Strandtmann(12), John C. Hodges(11), James M. Hamby(10), Marvin P. Cohen(6), Michael D. Taylor(5), Annette M. Doherty(5), C. John Blankley(5), Robert L. Panek(5), M. VON STRANDTMANN(5), Anne M. Doherty(5), Cleo J. C. Connolly(4), Wayne D. Klohs(4), William L. Elliott(4), Gina H. Lu(4), Tawny K. Dahring(4), Hussein Hallak(4), H. D. Hollis Showalter(4), Brian L. Batley(4), M. L. HOEFLE(4)