Karen Vana

Ludwig-Maximilians-Universität München — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index465citations13works0.02yr avg
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Research Topics

Prion Diseases and Protein Misfolding(11), RNA regulation and disease(7), Neurological diseases and metabolism(3), RNA Research and Splicing(2), Monoclonal and Polyclonal Antibodies Research(2)

Publications13 total

Prion Interaction with the 37-kDa/67-kDa Laminin Receptor on Enterocytes as a Cellular Model for Intestinal Uptake of Prions
Journal of Molecular Biology·2010· 26 citedOpen Access
Scrapie-Infected Transgenic Mice Expressing a Laminin Receptor Decoy Mutant Reveal a Prolonged Incubation Time Associated with Low Levels of PrPres
Journal of Molecular Biology·2009· 15 cited
LRP/LR as an Alternative Promising Target in Therapy of Prion Diseases, Alzheimers Disease and Cancer
Infectious Disorders - Drug Targets·2009· 38 cited
Microinjection of lentiviral vectors expressing small interfering RNAs directed against laminin receptor precursor mRNA prolongs the pre-clinical phase in scrapie-infected mice
Journal of General Virology·2008· 21 cited
Subcellular localization of prion proteins and the 37 kDa/67 kDa laminin receptor fused to fluorescent proteins
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2008· 23 citedOpen Access
Therapeutic approaches for prion disorders
Expert Review of Anti-infective Therapy·2007· 60 cited
TNF‐dependent overexpression of CCL21 is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder
European Journal of Immunology·2007· 13 citedOpen Access
Novel Aspects of Prions, Their Receptor Molecules, and Innovative Approaches for TSE Therapy
Cellular and Molecular Neurobiology·2006· 57 citedOpen Access
A Trans-dominant Negative 37 kDa/67 kDa Laminin Receptor Mutant Impairs PrPSc Propagation in Scrapie-infected Neuronal Cells
Journal of Molecular Biology·2006· 35 cited
The 37kDa/67kDa laminin receptor as a therapeutic target in prion diseases: potency of antisense LRP RNA, siRNAs specific for LRP mRNA and a LRP decoy mutant
Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)·2006Open Access
Knock-Down of the 37-kDa/67-kDa Laminin Receptor in Mouse Brain by Transgenic Expression of Specific Antisense LRP RNA
Transgenic Research·2004· 19 cited
The 37 kDa/67 kDa laminin receptor is required for PrPSc propagation in scrapie‐infected neuronal cells
EMBO Reports·2003· 9 citedOpen Access
The 37 kDa/67 kDa laminin receptor is required for PrP <sup>Sc</sup> propagation in scrapie‐infected neuronal cells
EMBO Reports·2003· 149 citedOpen Access

Frequent Co-authors

Stefan Weiß(10), Chantal Zuber(4), Christoph Leucht(3), Corinne Ida Lasmézas(3), Daphne Nikles(3), Heike Pflanz(3), Steve Simoneau(2), Clémence Rey(2), Roman Rieger(2), Heike Ludewigs(2), Dominika Kolodziejczak(2), Gerda Mitteregger(2), Claudia Pace(2), Ingrid Renner‐Müller(2), Eckhard Wolf(2), Inga Zerr(1), Georgeta Zemora(1), Ann-Katrin Bergmann(1), Bianca Da Costa Dias(1), Katarina Jovanović(1)