Joseph L. Regan

Irish Life (Ireland) — Ireland

Medicine · Health Sciences

15h-index1.2kcitations31works4.02yr avg
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Research Topics

Cancer Cells and Metastasis(25), Cancer Genomics and Diagnostics(8), Epigenetics and DNA Methylation(5), Cancer-related Molecular Pathways(4), Cancer Research and Treatments(4)

Publications31 total

Abstract 1566: Cancer metastasis and stemness: The metastasis-inducer MACC1 regulates LGR5 to promote cancer stem cell-like properties in colorectal cancer
Cancer Research·2024
MACC1 Regulates LGR5 to Promote Cancer Stem Cell Properties in Colorectal Cancer
Cancers·2024· 8 citedOpen Access
Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis
iScience·2022· 26 citedOpen Access
Protocol for isolation and functional validation of label-retaining quiescent colorectal cancer stem cells from patient-derived organoids for RNA-seq
STAR Protocols·2022· 2 citedOpen Access
Immunofluorescence staining of colorectal cancer patient-derived organoids
Methods in cell biology·2022· 8 cited
RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence
iScience·2021· 13 citedOpen Access
RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence
2021Open Access
Identification of a Nervous System Gene Expression Signature in Colon Cancer Stem Cells Reveals a Role for Neural Crest Regulators <i>EGR2</i> and <i>SOX2</i> in Tumorigenesis
2021Open Access
Generation of Patient-Derived Colorectal Cancer Organoids for RAS Studies
Methods in molecular biology·2021· 3 cited
Integrating Single Cell RNA-Sequencing and Functional Assays to Decipher Mammary Cell States and Lineage Hierarchies
2020
Integrating single-cell RNA-sequencing and functional assays to decipher mammary cell states and lineage hierarchies
npj Breast Cancer·2020· 18 citedOpen Access
Integrating Single Cell RNA-Sequencing Analyses and Functional Assays to Decipher Cell Differentiation Hierarchies in the Mammary Epithelium
Preprints.org·2019Open Access
Cell fate in colon cancer stem cells: To GLI or not to GLI?*
Molecular & Cellular Oncology·2018· 3 citedOpen Access
PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling
Cell Death and Disease·2018· 34 citedOpen Access
Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells
Cell Reports·2017· 134 citedOpen Access
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Nature Communications·2017· 341 citedOpen Access
Abstract 1715: Whole transcriptome analysis of patient-derived 3D in vitro and xenograft models of colon cancer identifies placental genes required for the survival of cancer stem cells
Cancer Research·2016
Abstract 1714: The role of Hedgehog signaling in the regulation of human colon cancer stem cells
Cancer Research·2016
Abstract 977: 3D-models of patient-derived colon tumors for the identification of genetic factors important in the regulation of cancer stem cells
Cancer Research·2015
Abstract 3875: Functional and molecular characterization of colon cancer stem cells in tumor heterogeneity and disease relapse using a 3D-model of patient-derived tumors
Cancer Research·2014
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Frequent Co-authors

Christian Regenbrecht(12), Dirk Schumacher(11), Martin Lange(11), Matthew J. Smalley(11), David Henderson(10), Johannes Haybaeck(10), Ulrich Keilholz(10), Stephanie Staudte(8), Dominik Mumberg(8), Reinhold Schäfer(7), Hans Lehrach(6), Howard Kendrick(6), Andreas Steffen(6), Ralf Lesche(6), Joern Toedling(6), Nicole Golob‐Schwarzl(4), Thibaud Jourdan(4), Balázs Győrffy(4), Reinhold Schaefer(4), Karsten Boehnke(3)