Daniel J. Kosman

University at Buffalo, State University of New York — United States

Nursing · Health Sciences

53h-index7.6kcitations165works1.92yr avg
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Research Topics

Trace Elements in Health(66), Iron Metabolism and Disorders(29), Metal-Catalyzed Oxygenation Mechanisms(29), Enzyme-mediated dye degradation(28), Fungal and yeast genetics research(27)

Publications165 total

Potent antioxidant and mitochondrial-protective effects of ATH434, a moderate affinity iron chaperone
Journal of Biological Chemistry·2025Open Access
Brain microvascular endothelial cells differentiated from a Friedreich’s Ataxia patient iPSC are deficient in tight junction protein expression and paracellularly permeable
Frontiers in Molecular Neuroscience·2025· 1 citedOpen Access
Potent antioxidant and mitochondrial-protective effects of ATH434, a novel therapeutic with moderate iron-binding affinity, in HT22 and iPSC-derived cellular models of oxidative stress
Free Radical Biology and Medicine·2024
Investigating the protective effects of ATH434 in hemin-induced ferroptosis in HT-22 neurons
Free Radical Biology and Medicine·2024
ATH434, a promising iron-targeting compound for treating iron regulation disorders
Metallomics·2024· 4 citedOpen Access
Calcium and IL-6 regulate the anterograde trafficking and plasma membrane residence of the iron exporter ferroportin to modulate iron efflux
Journal of Biological Chemistry·2024· 6 citedOpen Access
Loss of filamentous actin, tight junction protein expression, and paracellular barrier integrity in frataxin-deficient human brain microvascular endothelial cells—implications for blood-brain barrier physiology in Friedreich’s ataxia
Frontiers in Molecular Biosciences·2024· 2 citedOpen Access
Decreased filamentous actin and tight junction protein expression, and paracellular permeability in Frataxin-deficient human brain microvascular endothelial cells – implications for blood-brain barrier integrity in Friedreich's Ataxia
Research Square (Research Square)·2023Open Access
Tuning the Type 1 Reduction Potential of Multicopper Oxidases: Uncoupling the Effects of Electrostatics and H-Bonding to Histidine Ligands
Journal of the American Chemical Society·2023· 19 citedOpen Access
Decision letter: MEMO1 binds iron and modulates iron homeostasis in cancer cells
2023Open Access
Frataxin-deficient human brain microvascular endothelial cells lose polymerized actin and are paracellularly permeable –implications for blood-brain barrier integrity in Friedreich’s Ataxia
2023· 2 citedOpen Access
Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells
Journal of Biological Chemistry·2022· 11 citedOpen Access
Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention
Frontiers in Neurology·2022· 14 citedOpen Access
The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells
PLoS ONE·2021· 19 citedOpen Access
Molecular Defects in Friedreich’s Ataxia: Convergence of Oxidative Stress and Cytoskeletal Abnormalities
Frontiers in Molecular Biosciences·2020· 25 citedOpen Access
Transition Metal Ion Uptake in Yeasts and Filamentous Fungi
2020· 4 cited
A holistic view of mammalian (vertebrate) cellular iron uptake
Metallomics·2020· 22 citedOpen Access
Rapid Decay of the Native Intermediate in the Metallooxidase Fet3p Enables Controlled Fe<sup>II</sup> Oxidation for Efficient Metabolism
Journal of the American Chemical Society·2020· 12 citedOpen Access
Suppl. Data 1.xlsx
Figshare·2020Open Access
The solute carriers ZIP8 and ZIP14 regulate manganese accumulation in brain microvascular endothelial cells and control brain manganese levels
Journal of Biological Chemistry·2019· 45 citedOpen Access
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Frequent Co-authors

Edward I. Solomon(9), Richard Hassett(8), Liliana Quintanar(7), Christopher S. Stoj(7), Ryan C. McCarthy(6), Scott Severance(6), Annette M. Romeo(4), Tzu-Pin Wang(4), Arvinder Singh(3), E C Chang(3), Anthony J. Augustine(3), Alexander B. Taylor(2), P. John Hart(2), Lynn Ziegler(2), Keith O. Hodgson(2), Britt Hedman(2), Navjot Kaur(2), Amy E. Palmer(2), Joern Jungmann(1), Hans‐Albert Reins(1)