David K. Worthylake

Louisiana State University Health Sciences Center New Orleans — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index4.2kcitations65works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(14), Cellular transport and secretion(12), Microtubule and mitosis dynamics(11), HIV Research and Treatment(9), Protein Structure and Dynamics(7)

Publications64 total

ISG15 dysregulates endoplasmic reticulum-mitochondrial contacts and calcium homeostasis in Ataxia telangiectasia
Cellular Signalling·2025
Proteomic analysis of central amygdala systems regulated by the glucocorticoid receptor antagonist mifepristone in the context of alcohol dependence
Physiology·2024
Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis
Viruses·2023· 5 citedOpen Access
Correction to: A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming
Oncogene·2023· 1 citedOpen Access
Abstract 1858: Active and allosteric site evolution directs ordered water use in kinesin catalysis
Journal of Biological Chemistry·2023Open Access
A combination of novel NSC small molecule inhibitor along with doxorubicin inhibits proliferation of triple-negative breast cancer through metabolic reprogramming
Oncogene·2022· 9 cited
Hippo signaling pathway: A comprehensive gene expression profile analysis in breast cancer
Biomedicine & Pharmacotherapy·2022· 20 citedOpen Access
Small Molecule Anticancer Compound Modulates Cell Cycle DNA Damage Response Pathway and Inhibit Tumorigenesis in Triple Negative Breast Cancer
The FASEB Journal·2022
Circulating Exosomal Proteins are linked to Neuropathogenesis in SIV‐infected Rhesus Macaque: A Proteomic Approach
The FASEB Journal·2022
Crystal Structure of the DH/PH Fragment of Dbs without Bound GTPase
UNC Libraries·2021Open Access
Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange
UNC Libraries·2021Open Access
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange
UNC Libraries·2020Open Access
The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
UNC Libraries·2020Open Access
Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42
Journal of Biological Chemistry·2020· 21 citedOpen Access
Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope
Scientific Reports·2017· 20 citedOpen Access
The IQGAP1 N-Terminus Forms Dimers, and the Dimer Interface Is Required for Binding F-Actin and Calcium-Bound Calmodulin
Biochemistry·2016· 18 cited
Design and<i>In Vivo</i>Characterization of Immunoconjugates Targeting HIV gp160
Journal of Virology·2016· 21 citedOpen Access
The Structural Basis for Cdc42-Induced Dimerization of IQGAPs
Structure·2016· 44 citedOpen Access
IQGAP1 calponin homology domain fragment (CHDF) mutant K161C under oxidizing conditions
2016
N-Terminal Coiled-Coils in the Human Kinesin-5 and Kinesin-1 Stalk are Sufficient for Tetrameric Organization
Biophysical Journal·2016Open Access
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Frequent Co-authors

John Sondek(12), Kent L. Rossman(9), Courtney Parke(8), Wesley I. Sundquist(7), Christopher P. Hill(7), Louis LeCour(7), Jessie J. Guidry(7), Jason T. Snyder(5), Edward Wojcik(5), Sun‐Young Kim(5), Laurie Betts(4), Vinodh B. Kurella(4), Hassan Yousefi(4), Suresh K. Alahari(4), Theresa Gamble(3), F.F. Vajdos(3), Sanghee Yoo(3), David P. Siderovski(3), Wendy M. Pruitt(3), Channing J. Der(3)