Alexandra Borodovsky

Nurix (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index1.6kcitations48works0.02yr avg
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Research Topics

Adenosine and Purinergic Signaling(14), Cancer Immunotherapy and Biomarkers(9), Glioma Diagnosis and Treatment(8), Epigenetics and DNA Methylation(8), Hedgehog Signaling Pathway Studies(6)

Publications48 total

Abstract 1651: NRX-0305: a pan-mutant BRAF degrader with broad preclinical efficacy, brain penetrance, and synergistic potential with MEKi across class 1/2/3 BRAF-mutant cancers
Cancer Research·2025
810 NX-1607, a small molecule inhibitor of CBL-B, enhances anti-PD-1-mediated tumor growth inhibition by reshaping intratumoral innate and adaptive immune response
Regular and Young Investigator Award Abstracts·2023Open Access
NX‐0255 AND NX‐1607, SMALL MOLECULE INHIBITORS OF CBL‐B, ARE EFFICACIOUS IN COMBINATION WITH ADOPTIVE CELL THERAPY OR RITUXIMAB IN PRECLINICAL MOUSE MODELS OF LYMPHOMA
Hematological Oncology·2023Open Access
Data from Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor
2023Open Access
Supplementary Figure 1 from Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor
2023Open Access
Supplementary Figure 1 from Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor
2023Open Access
Data from Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor
2023Open Access
Transplantable Syngeneic Murine Tumor Models
2022· 1 cited
Abstract 573: <i>Ex-vivo</i> inhibition of CBL-B with a novel small molecule inhibitor, NX-0255, enhances persistence and anti-tumor activity of adoptively transferred CD8+ T cells in mouse tumor models
Cancer Research·2022· 1 cited
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase
Journal of Medicinal Chemistry·2021· 27 citedOpen Access
Abstract 1595: Small molecule inhibition of the ubiquitin ligase CBL-B results in potent T and NK cell mediated anti-tumor response
Cancer Research·2021· 10 cited
Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model
Frontiers in Immunology·2021· 15 citedOpen Access
A pharmacokinetic–pharmacodynamic model for the MET tyrosine kinase inhibitor, savolitinib, to explore target inhibition requirements for anti‐tumour activity
British Journal of Pharmacology·2020· 11 citedOpen Access
Small molecule AZD4635 inhibitor of A<sub>2A</sub>R signaling rescues immune cell function including CD103<sup>+</sup> dendritic cells enhancing anti-tumor immunity
Journal for ImmunoTherapy of Cancer·2020· 96 citedOpen Access
Retracted
Journal for ImmunoTherapy of Cancer·2020Open Access
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Journal for ImmunoTherapy of Cancer·2020· 114 citedOpen Access
Abstract A87: The A2AR antagonist AZD4635 prevents adenosine-mediated immunosuppression in tumor microenvironment and enhances antitumor immunity partly by enhancing CD103+ dendritic cells
Cancer Immunology Research·2020· 2 cited
A pharmacokinetic-pharmacodynamic model for the MET-TKI, savolitinib, to explore target inhibition requirements for anti-tumour activity
Authorea·2020Open Access
Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response
Clinical Cancer Research·2020· 96 cited
Immunosuppressive adenosine - a novel treatment target for multiple myeloma
Clinical Lymphoma Myeloma & Leukemia·2019
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Frequent Co-authors

Kris F. Sachsenmeier(12), Richard Woessner(11), Alwin G. Schuller(9), Gregory J. Riggins(8), Gregory J. Riggins(7), Charles M. Rudin(6), Jon Chung(6), Fred Bunz(6), Celina M. D’Cruz(6), Andrew R. Larsen(5), Kelly Goodwin(5), Ryan B. Rountree(5), Gwenn M. Hansen(5), Carl Hay(4), Christine M. Barbon(4), Yanjun Wang(4), Minwei Ye(4), Laura B. Prickett(4), Miles Congreve(4), Wenlin Shao(4)