Matthew D. Scharff

Albert Einstein College of Medicine — United States

Medicine · Health Sciences

76h-index19.0kcitations306works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(141), T-cell and B-cell Immunology(85), Glycosylation and Glycoproteins Research(76), Protein purification and stability(32), Fungal Infections and Studies(30)

Publications306 total

Dynamic crosstalk between CLL cells and lymph node fibroblasts promotes a pro-tumor microenvironment
Blood·2025Open Access
B CELL RECEPTOR SEQUENCING REVEALS DISTINCT SELECTION OF AUTOREACTIVE AGE/AUTOIMMUNITY-ASSOCIATED B CELLS IN PATIENTS WITH SLE
The Journal of Rheumatology·2025Open Access
SELECTION OF ANTI-NUCLEAR ANTIGEN (ANA) REACTIVE B CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS
2025
Eradication of the CLECL1+ CLL Subset That Is Prone to Carrying Novel Genomic Mutations and Promoting a Pro-Tumor Microenvironment By a Series of New Monoclonal Antibodies Reactive with Distinct Target Epitopes
Blood·2024
Error-Prone DNA Mismatch and Base Excision Repair in the Somatic Hypermutation of Antibody Variable Regions
Elsevier eBooks·2024
Locus-specific proteomics identifies new aspects of the chromatin context involved in V region somatic hypermutation
2022· 2 citedOpen Access
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i>Exo1D173A</i> mice
Nucleic Acids Research·2022· 19 citedOpen Access
Correction to: Intraclonal Complexity in Chronic Lymphocytic Leukemia: Fractions Enriched in Recently Born/Divided and Older/Quiescent Cells
Molecular Medicine·2022· 2 citedOpen Access
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions
Proceedings of the National Academy of Sciences·2021· 18 citedOpen Access
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> mice
2021· 1 citedOpen Access
A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes
PLoS Computational Biology·2021· 8 citedOpen Access
Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes
Proceedings of the National Academy of Sciences·2021· 22 citedOpen Access
Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
Frontiers in Oncology·2021· 15 citedOpen Access
HIRA-dependent H3.3 deposition and its modification facilitate somatic hypermutation of immunoglobulin gene by maintaining the proper chromatin context and transcription
The Journal of Immunology·2021· 1 cited
AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes
Frontiers in Immunology·2020· 35 citedOpen Access
CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation
Blood Advances·2020· 13 citedOpen Access
Monoclonal Antibodies Reveal the Structural Basis of Antibody Diversity
2019
Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells
mBio·2018· 10 citedOpen Access
The Medical Uses of Monoclonal Antibodies
2016· 1 cited
Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation
Elsevier eBooks·2016
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Frequent Co-authors

Arturo Casadevall(15), Jean Mukherjee(7), Jacob V. Maizel(4), Philippe Valadon(4), Alberto Martín(4), Betty Diamond(4), David H. Margulies(3), Sergio Roa(3), Caroline J. Woo(3), Reuven Laskov(3), Winfried Edelmann(3), Philip Coffino(3), Gabriel Nussbaum(3), DAVID O. WHITE(2), Myron F. Goodman(2), Jonathan U. Peled(2), Fei Kuang(2), Maria D. Iglesias-Ussel(2), Betty Diamond(2), Ziqiang Li(2)