Christian Maasch

Noxxon Pharma (Germany) — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.4kcitations39works7.52yr avg
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Research Topics

Advanced biosensing and bioanalysis techniques(9), RNA Interference and Gene Delivery(7), Protein Kinase Regulation and GTPase Signaling(6), Complement system in diseases(6), DNA and Nucleic Acid Chemistry(5)

Publications39 total

Ultrasensitive Detection of Chemokines in Clinical Samples with Graphene‐Based Field‐Effect Transistors (Adv. Mater. 52/2024)
Advanced Materials·2024· 1 citedOpen Access
Ultrasensitive Detection of Chemokines in Clinical Samples with Graphene‐Based Field‐Effect Transistors
Advanced Materials·2024· 14 citedOpen Access
Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis
Anesthesiology·2020· 27 citedOpen Access
Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2
Nature Communications·2015· 96 citedOpen Access
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer
Nature Communications·2015· 86 citedOpen Access
Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy
Basic Research in Cardiology·2015· 43 citedOpen Access
A novel <scp>CGRP</scp>‐neutralizing <scp>S</scp>piegelmer attenuates neurogenic plasma protein extravasation
British Journal of Pharmacology·2015· 19 citedOpen Access
SDF-1 Inhibition Targets the Bone Marrow Niche for Cancer Therapy
Cell Reports·2014· 135 citedOpen Access
High Resolution Structure of a Mirror-Image RNA Oligonucleotide Aptamer in Complex with the Chemokine CCL2
2014
Structural basis for inhibition of complement C5a by an L-RNA aptamer
Acta Crystallographica Section A Foundations and Advances·2014Open Access
<i>In Vitro</i>Selection against Small Targets
2014
Neutralizing the complement component C5a protects against lung injury and extrapulmonary organ injury in pneumococcal pneumonia induced sepsis
Pneumologie·2014· 4 cited
The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization
Blood·2013· 229 citedOpen Access
A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis
Molecular Therapy·2013· 85 citedOpen Access
A Mixed Mirror-image DNA/RNA Aptamer Inhibits Glucagon and Acutely Improves Glucose Tolerance in Models of Type 1 and Type 2 Diabetes
Journal of Biological Chemistry·2013· 54 citedOpen Access
Targeting complement component 5a promotes vascular integrity and limits airway remodeling
Proceedings of the National Academy of Sciences·2013· 70 citedOpen Access
Hematopoietic Stem and Progenitor Cell Mobilization in Mice and Humans by a First-in-Class Mirror-Image Oligonucleotide Inhibitor of CXCL12
Clinical Pharmacology & Therapeutics·2013· 85 citedOpen Access
The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys
Blood·2013· 152 citedOpen Access
Mode of Action of the SDF-1/CXCL12 Inhibiting Spiegelmer® Nox-A12 and Its Impact On Chronic Lymphocytic Leukemia (CLL) Cell Motility and Chemosensitization
Blood·2012· 3 cited
Identification of a novel C5a-inhibiting human and mouse-specific Spiegelmer® for treatment of septic shock and its proof of concept in the CLP mouse model
Immunobiology·2012
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Frequent Co-authors

Axel Vater(16), Sven Klußmann(15), Klaus Buchner(14), Werner G. Purschke(13), Friedrich C. Luft(11), Dirk Eulberg(9), Carsten Lindschau(7), Hermann Haller(7), Stefan Vonhoff(6), Kai Hoehlig(6), Hermann Haller(5), Dirk Zboralski(4), Anna Kruschinski(4), Simone Sell(4), JP Klußmann(4), Albrecht Hempel(3), Duska Dragun(3), Maren Wellner(3), Julia Hoellenriegel(2), Jan A. Burger(2)