Gary S. Firestein

Queen Elizabeth Hospital Birmingham — United Kingdom

Medicine · Health Sciences

101h-index46.9kcitations453works11.62yr avg
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Research Topics

Rheumatoid Arthritis Research and Therapies(149), Systemic Lupus Erythematosus Research(75), Cytokine Signaling Pathways and Interactions(63), Monoclonal and Polyclonal Antibodies Research(57), NF-κB Signaling Pathways(50)

Publications452 total

Spatial transcriptomics reveals distinct inflammatory and adaptive immune properties of rheumatoid arthritis synovial fibroblasts
2025Open Access
Epigenetic control of pathogenic CD4 T cell polarization during progression to rheumatoid arthritis 3989
The Journal of Immunology·2025Open Access
The B cell compartment exhibits a pro-inflammatory skewing during progression to Rheumatoid Arthritis 4776
The Journal of Immunology·2025Open Access
Dysregulated Immune Response to Perturbation from Vaccination in ACPA+ Individuals at Risk for Rheumatoid Arthritis 9277
The Journal of Immunology·2025Open Access
Systemic inflammation and transcriptional reprogramming contribute to progression to active rheumatoid arthritis in ACPA+ individuals 4474
The Journal of Immunology·2025Open Access
Process evaluation and lessons learned from the formation of a multi-sector partnership: the Healing Experiences of Adversity among Latinos (HEALthy4You)
Frontiers in Health Services·2025· 1 citedOpen Access
Senescent Activated Naive B Cells Promote Anti-Citrullinated Antigen T Cell Responses and the Transition to Clinical Rheumatoid Arthritis
2025· 1 citedOpen Access
Optimization of a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors
JCI Insight·2025Open Access
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Science Translational Medicine·2025· 7 citedOpen Access
Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis
Arthritis Research & Therapy·2025· 3 citedOpen Access
Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain
Journal of Biological Chemistry·2025Open Access
Building biorepositories in the midst of a pandemic
UNC Libraries·2025Open Access
POS1376 SPUTUM CALPROTECTIN LEVELS DO NOT ADD TO ABILITY OF SPUTUM ANTI-CCP AND RF TO PREDICT FUTURE DEVELOPMENT OF RA IN SERUM ANTI-CCP POSITIVE INDIVIDUALS AT-RISK FOR RA
Annals of the Rheumatic Diseases·2025Open Access
Multi-lineage transcriptional and cell communication signatures define pathways in individuals at-risk for developing rheumatoid arthritis that initiate and perpetuate disease
2025Open Access
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis
Journal of Clinical Investigation·2025· 22 citedOpen Access
Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis
2025· 1 citedOpen Access
Granzyme K activates the entire complement cascade
Nature·2025· 68 citedOpen Access
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
Nature Communications·2024· 10 citedOpen Access
Systemic inflammation and lymphocyte activation precede rheumatoid arthritis
2024· 5 citedOpen Access
Epigenetic trajectory predicts development of clinical rheumatoid arthritis in anti-citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)
2024· 4 citedOpen Access
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Frequent Co-authors

Nathan J. Zvaifler(11), David L. Boyle(8), José María Álvaro‐Gracia(5), Ellen M. Gravallese(4), Sanna Rosengren(4), Iain B. McInnes(3), Fan Zhang(3), Kevin Wei(3), Kamil Slowikowski(3), Deepak A. Rao(3), Susan M. Goodman(3), Darren Tabechian(3), Laura B. Hughes(3), Gerald F. Watts(3), A. Helena Jonsson(3), Javier Rangel‐Moreno(3), Nida Meednu(3), Arthur M. Mandelin(3), Brendan F. Boyce(3), Edward F. DiCarlo(3)