Hiroaki Aikawa

Lord Corporation (United States) — United States

Computer Science · Physical Sciences

20h-index1.3kcitations126works1.72yr avg
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Research Topics

Advanced Mathematical Modeling in Engineering(41), Advanced Harmonic Analysis Research(27), Nonlinear Partial Differential Equations(23), Holomorphic and Operator Theory(19), Numerical methods in inverse problems(13)

Publications126 total

A case study for visualizing oligonucleotide therapeutics distribution in rat organs using MALDI mass spectrometry imaging
Drug Metabolism and Pharmacokinetics·2025
Development of a PAC-LC-MS/MS method for simultaneous quantification of mipomersen, its metabolites, and analogues in tissue samples
Drug Metabolism and Pharmacokinetics·2025
Versatile intact LC–MS method for evaluating the drug–antibody ratio and drug load distribution of antibody–drug conjugates in human plasma
Journal of Chromatography B·2025· 5 cited
Tissue 2-hydroxyglutarate and preoperative seizures in patients with diffuse gliomas
WFNOS 2022 Abstract Book·2022Open Access
Intrinsic Ultracontractivity for Domains in Negatively Curved Manifolds
Computational Methods and Function Theory·2021· 1 citedOpen Access
Intrinsic ultracontractivity for domains in negatively curved manifolds
arXiv (Cornell University)·2021Open Access
Global integrability of supertemperatures
Mathematische Zeitschrift·2020· 1 cited
MPC-11 IDH1/2 MUTATIONS ARE ASSOCIATED WITH SEIZURE ONSET AND VETRY IMAGING IN PATIENTS WITH DIFFUSE GLIOMA VISUALIZING 2-HYDROXYGLUTARATE BY MASS SPECTRUM
Neuro-Oncology Advances·2019Open Access
Potential theoretic notions related to integrability of superharmonic functions and supertemperatures
Analysis and Mathematical Physics·2019· 1 cited
Applications of MALDI mass spectrometry imaging for pharmacokinetic studies during drug development
Drug Metabolism and Pharmacokinetics·2019· 62 cited
Distribution of erlotinib in rash and normal skin in cancer patients receiving erlotinib visualized by matrix assisted laser desorption/ionization mass spectrometry imaging
Oncotarget·2018· 18 citedOpen Access
Novel high-sensitive drug detecting, PID method reveals intra-tumor pharmacokinetics of trastuzumab and factors affect to its remarkable heterogeneity
Proceedings for Annual Meeting of The Japanese Pharmacological Society·2018Open Access
MALDI mass spectrometry imaging of erlotinib administered in combination with bevacizumab in xenograft mice bearing B901L, EGFR-mutated NSCLC cells
Scientific Reports·2017· 16 citedOpen Access
Heterogeneous distribution of alectinib in neuroblastoma xenografts revealed by matrix‐assisted laser desorption ionization mass spectrometry imaging: a pilot study
British Journal of Pharmacology·2017· 21 citedOpen Access
Evaluation of the heterogeneous tissue distribution of erlotinib in lung cancer using matrix-assisted laser desorption ionization mass spectrometry imaging
Scientific Reports·2017· 28 citedOpen Access
High‐performance liquid chromatography–tandem mass spectrometry for simultaneous determination of raltegravir, dolutegravir and elvitegravir concentrations in human plasma and cerebrospinal fluid samples
Biomedical Chromatography·2017· 19 cited
Abstract 4647: Mass spectrometric analysis of oncometabolite 2-hydroxyglutarate in clinical gliomas with the isocitrate dehydrogenase-1 mutation
Cancer Research·2017
Abstract 2872: Quantitative mass spectrometry imaging of erlotinib in skin rashes of cancer patients receiving erlotinib
Cancer Research·2017
Dichotomy of global capacity density in metric measure spaces
Advances in Calculus of Variations·2017· 2 citedOpen Access
MPTH-22. SERUM 2-HYDROXYGLUTARATE (2HG) LEVELS ARE CORRELATED WITH TISSUE 2HG LEVELS IN ISOCITRATE DEHYDROGENASE 1 AND 2 GENES (IDH1/2)-MUTATED GLIOMAS BUT NOT IN IDH1/2-WILDTYPE GLIOMAS
Neuro-Oncology·2016Open Access
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Frequent Co-authors

Akinobu Hamada(9), Mitsuhiro Hayashi(7), Yasuhiro Fujiwara(5), Masanobu Nishidate(3), Shoraku Ryu(3), Torbjörn Lundh(3), Nageswari Shanmugalingam(2), Nagakazu Furuya(2), Makiko Yamashita(2), Noboru Yamamoto(2), Kenji Tamura(2), Mayu Ohuchi(2), Nakao Hayashi(2), Tero Kilpeläinen(1), Xiao Zhong(1), Kouji Tanaka(1), Naoyuki Nakada(1), Shinichi Miura(1), Tatsuya Higashi(1), Yoshinori Ikarashi(1)